{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T20:27:01Z","timestamp":1785356821531,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T00:00:00Z","timestamp":1446681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"German Statutory Accident Insurance (Deutsche Gesetzliche Unfallversicherung; DGUV)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Epoxy resin systems (<jats:styled-content style=\"fixed-case\">ERS<\/jats:styled-content>s), consisting of resins, reactive diluents, and hardeners, are indispensable in many branches of industry. In order to develop less sensitizing <jats:styled-content style=\"fixed-case\">ERS<\/jats:styled-content> formulations, knowledge of the sensitizing properties of single components is mandatory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To analyse the frequency of sensitization in the patients concerned, as one integral part of a research project on the sensitizing potency of epoxy resin compounds (<jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>\u20100324).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of data from the <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nformation <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>etwork of <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>epartments of <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ermatology (<jats:styled-content style=\"fixed-case\">IVDK<\/jats:styled-content>), 2002\u20132011, and a comparison of reaction frequencies with (surrogate) exposure data, were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Almost half of the patients sensitized to epoxy resin were additionally sensitized to reactive diluents or hardeners. Among the reactive diluents, 1,6\u2010hexanediol diglycidyl ether was the most frequent allergen, followed by 1,4\u2010butanediol diglycidyl ether, phenyl glycidyl ether, and <jats:italic>p<\/jats:italic>\u2010tert\u2010butylphenyl glycidyl ether. Among the hardeners, <jats:italic>m<\/jats:italic>\u2010xylylene diamine (<jats:styled-content style=\"fixed-case\">MXDA<\/jats:styled-content>) and isophorone diamine (<jats:styled-content style=\"fixed-case\">IPDA<\/jats:styled-content>) were the most frequent allergens. According to the calculated exposure\u2010related frequency of sensitization, <jats:styled-content style=\"fixed-case\">MXDA<\/jats:styled-content> seems to be a far more important sensitizer than <jats:styled-content style=\"fixed-case\">IPDA<\/jats:styled-content>. Up to 60% of the patients sensitized to hardeners and 15\u201320% of those sensitized to reactive diluents do not react to epoxy resin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In cases of suspected contact allergy to an <jats:styled-content style=\"fixed-case\">ERS<\/jats:styled-content>, a complete epoxy resin series must be patch tested from the start.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12491","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T09:28:39Z","timestamp":1446715719000},"page":"83-93","source":"Crossref","is-referenced-by-count":26,"title":["Sensitization to reactive diluents and hardeners in epoxy resin systems. <scp>IVDK<\/scp> data 2002\u20132011. Part <scp>I<\/scp>: reaction frequencies"],"prefix":"10.1111","volume":"74","author":[{"given":"Johannes","family":"Geier","sequence":"first","affiliation":[{"name":"Information Network of Departments of Dermatology University of G\u00f6ttingen  37075 G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Lessmann","sequence":"additional","affiliation":[{"name":"Information Network of Departments of Dermatology University of G\u00f6ttingen  37075 G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Hillen","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Essen  45122 Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Skudlik","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Environmental Medicine, and Health Theory University of Osnabr\u00fcck  49069 Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Jappe","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Heidelberg  69115 Heidelberg Germany"},{"name":"Department of Dermatology University of L\u00fcbeck  23538 L\u00fcbeck Germany"},{"name":"Division of Clinical and Molecular Allergology Research Centre Borstel, Airway Research Centre North, Member of the German Centre for Lung Research  23845 Borstel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,5]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"Occupational skin diseases from epoxy compounds","volume":"159","author":"Jolanki R","year":"1991","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.44020920.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-07677-4_73"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-02035-3_51"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12280"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12369"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01634989-199106000-00004"},{"key":"e_1_2_7_9_1","unstructured":"HeineK KalberlahF HassauerMet\u2009al.Ranking von Stoffen in Epoxidharzsystemen aufgrund ihrer sensibilisierenden Wirkst\u00e4rken (FP\u20100324). Final report on the research project FP\u20100324 published online in German language December2012. Available at:http:\/\/www.bgbau.de\/gisbau\/fachthemen\/epoxi\/downloads\/Gesamtbericht.pdf(last accessed 19 March 2015)."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02834.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.5414\/DBP53107"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.0105-1873.2004.00406.x","article-title":"Guidelines for the descriptive presentation and statistical analysis of contact allergy data","volume":"51","author":"Uter W","year":"2005","journal-title":"Contact Dermatitis"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2009.06787.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00465.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.0309df.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01420.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01475.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2008.08.018"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(94)90112-0"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2005.05040"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx900193s"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01431.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02082.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2006.00806.x"},{"key":"e_1_2_7_25_1","first-page":"117","article-title":"Allergische Kontaktekzeme durch m\u2010Xylylen\u2010diamin in der Polyurethanseidenproduktion","volume":"38","author":"Richter G","year":"1990","journal-title":"Dermatol Beruf Umwelt"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01197.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-02035-3_53"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12491","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:07:08Z","timestamp":1696306028000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,5]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/cod.12491"],"URL":"https:\/\/doi.org\/10.1111\/cod.12491","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,5]]}}}