{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T14:44:37Z","timestamp":1782053077250,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T00:00:00Z","timestamp":1447372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cobalt is a strong skin sensitizer (grade 5 of 5 in the guinea\u2010pig maximization test) that is used in various industrial and consumer applications. To prevent sensitization to cobalt and elicitation of allergic cobalt dermatitis, information about the elicitation threshold level of cobalt is important.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify the dermatitis elicitation threshold levels in cobalt\u2010allergic individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Published patch test dose\u2013response studies were reviewed to determine the elicitation dose (<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>) levels in dermatitis patients with a previous positive patch test reaction to cobalt. A logistic dose\u2013response model was applied to data collected from the published literature to estimate <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> values. The 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) for the ratio of mean doses that can elicit a reaction in 10% (<jats:styled-content style=\"fixed-case\">ED<jats:sub>10<\/jats:sub><\/jats:styled-content>) of a population was calculated with <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ieller's method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On the basis of five included studies, the <jats:styled-content style=\"fixed-case\">ED<jats:sub>10<\/jats:sub><\/jats:styled-content> values of aqueous cobalt chloride ranged between 0.0663 and 1.95 \u00b5g cobalt\/cm<jats:sup>2<\/jats:sup>, corresponding to 30.8\u2013259 ppm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our analysis provides an overview of the doses of cobalt that are required to elicit allergic cobalt contact dermatitis in sensitized individuals, and thereby the basis for future prevention of cobalt allergy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12499","type":"journal-article","created":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T08:46:38Z","timestamp":1447404398000},"page":"105-109","source":"Crossref","is-referenced-by-count":25,"title":["Elicitation threshold of cobalt chloride: analysis of patch test dose\u2013response studies"],"prefix":"10.1111","volume":"74","author":[{"given":"Louise A.","family":"Fischer","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Copenhagen University Hospital Gentofte  DK\u20102900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Copenhagen University Hospital Gentofte  DK\u20102900 Hellerup 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