{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:19:38Z","timestamp":1778581178139,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T00:00:00Z","timestamp":1455494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>An allergic contact reaction is accompanied by high oxidative stress in the skin. Pretreatment of the skin with antioxidative substances could reduce the elicitation reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate, in a proof\u2010of\u2010principle study, whether pretreatment of the skin with the antioxidant ascorbic acid reduces the elicitation reaction to a <jats:italic>p<\/jats:italic>\u2010phenylenediamine (<jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>)\u2010containing hair dye in sensitized subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve subjects with contact allergy to <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>, a documented skin reaction to a hair dye simulation exposure model and a history of hair dye\u2010related skin complaints were included in this study. Skin areas on the forearms were, in a left versus right design, exposed to an emulsion with ascorbic acid and an emulsion without ascorbic acid, and then to a 2% <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>\u2010containing hair dye testing formulation. In addition, control areas were exposed to the emulsions and to the <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>\u2010containing hair dye formulation without pretreatment. Skin reactions were graded on <jats:styled-content style=\"fixed-case\">day (D)2<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">D3<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pretreatment with ascorbic acid emulsion resulted in a reduction in the elicitation reaction in 7 of 12 subjects at <jats:styled-content style=\"fixed-case\">D3<\/jats:styled-content> (<jats:italic>p<\/jats:italic> = 0.046). No statistically significant difference was observed at <jats:styled-content style=\"fixed-case\">D2<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pretreatment of the skin with the antioxidant ascorbic acid had an attenuating effect on the elicitation reaction to <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> in sensitized individuals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12535","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T09:15:07Z","timestamp":1455527707000},"page":"267-272","source":"Crossref","is-referenced-by-count":13,"title":["The role of the antioxidant ascorbic acid in the elicitation of contact allergic reactions to <i>p<\/i>\u2010phenylenediamine"],"prefix":"10.1111","volume":"74","author":[{"given":"Pieter\u2010Jan","family":"Coenraads","sequence":"first","affiliation":[{"name":"Department of Dermatology University Medical Center Groningen, University of Groningen  9700 RB Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana A.","family":"Vogel","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center Groningen, University of Groningen  9700 RB Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brunhilde","family":"Bl\u00f6meke","sequence":"additional","affiliation":[{"name":"Department of Environmental Toxicology Trier University  54296 Trier Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Goebel","sequence":"additional","affiliation":[{"name":"The Procter &amp; Gamble Company Central Product Safety  65823 Schwalbach am Taunus Germany"},{"name":"The Procter &amp; Gamble Company, Central Product Safety  1853 Strombeek\u2010Bever Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Roggeband","sequence":"additional","affiliation":[{"name":"The Procter &amp; Gamble Company Central Product Safety  65823 Schwalbach am Taunus Germany"},{"name":"The Procter &amp; Gamble Company, Central Product Safety  1853 Strombeek\u2010Bever Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.L.A.","family":"Schuttelaar","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center Groningen, University of Groningen  9700 RB Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(00)00482-2"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041340"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2010.22.3.269"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01399.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.02.038"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2007.05.004"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12311"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/aob\/mcf118"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01717.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.11.013"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10009.x"},{"key":"e_1_2_5_13_1","volume-title":"Opinion on: 2\u2010Methylresorcinol COLIPA No. A44 Adopted by the SCCP During the 18th Plenary Meeting on 16 December 2008","author":"Scientific Committee on Consumer Products","year":"2008"},{"key":"e_1_2_5_14_1","volume-title":"Opinion on: 2\u2010Methyl\u20105\u2010Hydroxyethylaminophenol COLIPA No. A31 Adopted by the SCCP During the 7th Plenary Meeting on 28 March 2006","author":"Scientific Committee on Consumer Products","year":"2006"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06742.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13751"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb15115.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2005.04.008"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2494.1985.tb00415.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2550100512"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04664.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.04.023"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2010.02.011"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-011-9659-1"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2001.00264.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12006"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2006.00887.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.209"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx900095r"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12535","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T07:30:54Z","timestamp":1696318254000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,15]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/cod.12535"],"URL":"https:\/\/doi.org\/10.1111\/cod.12535","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,15]]}}}