{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:44:54Z","timestamp":1789209894512,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T00:00:00Z","timestamp":1456444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010234","name":"Swedish Asthma and Allergy Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010234","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Hudfonden (the Welander-Finsen Foundation"},{"name":"Health & Medical Care Committee of the Region V\u00e4stra G\u00f6taland (ALF)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Limonene and linalool are common fragrance terpenes. Both oxidized <jats:italic>R<\/jats:italic><jats:italic>\u2010<\/jats:italic>limonene and oxidized linalool have recently been patch tested in an international setting, showing contact allergy in 5.2% and 6.9% of dermatitis patients, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate concomitant reactions between oxidized <jats:italic>R<\/jats:italic>\u2010limonene and oxidized linalool in consecutive dermatitis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Oxidized <jats:italic>R<\/jats:italic>\u2010limonene 3.0% (containing limonene hydroperoxides 0.33%) and oxidized linalool 6% (linalool hydroperoxides 1%) in petrolatum were tested in 2900 consecutive dermatitis patients in Australia, Denmark, Singapore, Spain, Sweden, and the United Kingdom.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 281 patients reacted to either oxidized <jats:italic>R<\/jats:italic>\u2010limonene or oxidized linalool. Of these, 25% had concomitant reactions to both compounds, whereas 29% reacted only to oxidized <jats:italic>R<\/jats:italic>\u2010limonene and 46% only to oxidized linalool. Of the 152 patients reacting to oxidized <jats:italic>R<\/jats:italic>\u2010limonene, 46% reacted to oxidized linalool, whereas 35% of the 200 patients reacting to oxidized linalool also reacted to oxidized <jats:italic>R<\/jats:italic>\u2010limonene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The majority of the patients (75%) reacted to only one of the oxidation mixtures, thus supporting the specificity of the reactions. The concomitant reactions to the two fragrance allergens suggest multiple sensitizations, which most likely reflect the exposure to the different fragrance materials in various types of consumer products. This is in accordance with what is generally seen for patch test reactions to fragrance materials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12545","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T11:42:16Z","timestamp":1456486936000},"page":"273-280","source":"Crossref","is-referenced-by-count":61,"title":["Oxidized limonene and oxidized linalool \u2013 concomitant contact allergy to common fragrance terpenes"],"prefix":"10.1111","volume":"74","author":[{"given":"Johanna","family":"Br\u00e5red Christensson","sequence":"first","affiliation":[{"name":"Department of Dermatology Sahlgrenska Academy at University of Gothenburg  413 45 Gothenburg Sweden"},{"name":"Dermatochemistry, Department of Chemistry and Molecular Biology University of Gothenburg  412 96 Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2010Therese","family":"Karlberg","sequence":"additional","affiliation":[{"name":"Dermatochemistry, Department of Chemistry and Molecular Biology University of Gothenburg  412 96 Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus E.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital, University of Southern Denmark  5000 Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University  205 02 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"The National Allergy Research Centre, Department of Dermato\u2010allergology Gentofte Hospital, University of Copenhagen  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Garcia\u2010Bravo","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Virgen Macarena  41007 Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Gim\u00e9nez Arnau","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar, Institut Mar d'Investigacions M\u00e9diques, Universitat Aut\u00f2noma  08003 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee\u2010Leok","family":"Goh","sequence":"additional","affiliation":[{"name":"National Skin Centre  308205 Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Nixon","sequence":"additional","affiliation":[{"name":"Occupational Dermatology Research and Education Centre, Skin and Cancer Foundation  3053 Victoria 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