{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:18:11Z","timestamp":1789525091551,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T00:00:00Z","timestamp":1455494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ethylhexylglycerin is a relatively new cosmetic ingredient that is used for its surfactant, emollient, skin\u2010conditioning and antimicrobial properties. Since 2002, it has been occasionally reported as a contact allergen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To report on 13 patients who presented with allergic contact dermatitis caused by ethylhexylglycerin, evaluated at two Belgian university patch test clinics during the period 1990\u20132015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>The patients were patch tested with the European baseline series, a cosmetic series, and \u2013 if indicated \u2013 additional series. Both the cosmetic products used and their single ingredients were patch tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All but one of the ethylhexylglycerin\u2010allergic patients were female, with a median age of 43 years (range: 29\u201381 years), most often suffering from dermatitis on the face, and sometimes on the hands and\/or axillae. As the culprit products, leave\u2010on cosmetics were identified, including a high number of proclaimed \u2018hypo\u2010allergenic\u2019 and \u2018preservative\u2010free\u2019 facial creams, sun protection creams, and deodorants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ethylhexylglycerin is a rare, but highly relevant, cosmetic sensitizer, even in those products advertised to be safe for consumers. Targeted patch testing with ethylhexylglycerin 5% pet. is very useful, and routine patch testing in a cosmetic series may be considered. Higher test concentrations might be indicated in selected cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12546","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T09:06:39Z","timestamp":1455527199000},"page":"281-288","source":"Crossref","is-referenced-by-count":40,"title":["Ethylhexylglycerin: a low\u2010risk, but highly relevant, sensitizer in \u2018hypo\u2010allergenic\u2019 cosmetics"],"prefix":"10.1111","volume":"74","author":[{"given":"Olivier","family":"Aerts","sequence":"first","affiliation":[{"name":"Department of Dermatology Antwerp University Hospital (UZA) and University of Antwerp (UA)  2650 Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lien","family":"Verhulst","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospitals K.U. Leuven  3000 Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Goossens","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospitals K.U. Leuven  3000 Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1091581813497766"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.470308_4.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01103.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01586.x"},{"key":"e_1_2_6_6_1","first-page":"134","article-title":"Allergic contact dermatitis from ethylhexylglycerin","volume":"23","author":"Dorschner R A","year":"2012","journal-title":"Dermatitis"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e31827596b1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e3182a5d8a9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12208"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2006.03.005"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12093"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12249"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01885.x"},{"key":"e_1_2_6_15_1","first-page":"165","volume-title":"Progr\u00e8s en Dermato\u2010Allergologie, Montpellier 2011","author":"Vigan M","year":"2011"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12546","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12546","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T07:30:56Z","timestamp":1696318256000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,15]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/cod.12546"],"URL":"https:\/\/doi.org\/10.1111\/cod.12546","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,15]]}}}