{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:38:35Z","timestamp":1792546715747,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T00:00:00Z","timestamp":1456704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2016,5]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n Topical remedies based on botanical ingredients are popular.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To assess: (i) the usage of botanical substances in subjects affected with itching and chronic vulvar complaints; (ii) the incidence of side\u2010effects associated with their use and the frequency of contact allergy; (iii) the diagnostic usefulness of patch testing.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Sixty\u2010six patients were provided with a questionnaire to assess the prevalence and type of topical botanical preparations used and the occurrence of adverse reactions. Patients were patch tested with (i) the Italian baseline series, (ii) a topical medicament series, and (iii) a botanical series.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Forty\u2010two patients (63.6%) reported the use of natural topical products on the vulva. Seven (16.7%) noted adverse reactions; 27 showed positive reactions with the baseline series; 14 (21.2%) had at least one relevant reaction, mainly to allergens in topical products and cosmetics; and 2 (3%) showed positive reactions to the botanical series. Of the 7 patients complaining of adverse effects of botanical products, 3 (42.8%) showed relevant sensitization.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The use of natural topical products is widespread among women affected with itching vulvar diseases. Contact dermatitis is a possible adverse effect. Botanical series are of questionable usefulness, owing to the wide variety of botanical ingredients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cod.12559","type":"journal-article","created":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T23:33:49Z","timestamp":1456788829000},"page":"289-294","source":"Crossref","is-referenced-by-count":16,"title":["Level of use and safety of botanical products for itching vulvar dermatoses. Are patch tests useful?"],"prefix":"10.1111","volume":"74","author":[{"given":"Monica","family":"Corazza","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Mediche \u2013 Sezione di Dermatologia e Malattie Infettive University of Ferrara 44100 Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annarosa","family":"Virgili","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche \u2013 Sezione di Dermatologia e Malattie Infettive University of Ferrara 44100 Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Toni","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche \u2013 Sezione di Dermatologia e Malattie Infettive University of Ferrara 44100 Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Minghetti","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche \u2013 Sezione di Dermatologia e Malattie Infettive University of Ferrara 44100 Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Tiengo","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche \u2013 Sezione di Dermatologia e Malattie Infettive University of Ferrara 44100 Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Borghi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche \u2013 Sezione di Dermatologia e Malattie Infettive University of Ferrara 44100 Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.2.232"},{"key":"e_1_2_6_3_1","first-page":"247","article-title":"Botanicals in dermatology: an evidence\u2010based review","volume":"11","author":"Reuter J","year":"2010","journal-title":"Am J Clin Dermatol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1363"},{"key":"e_1_2_6_5_1","first-page":"1084","article-title":"Botanical ingredients in cosmeceuticals","volume":"6","author":"Baumann L","year":"2007","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03822.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1992.tb03278.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06425.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00219.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03245.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2004.04009"},{"key":"e_1_2_6_12_1","first-page":"287","article-title":"Terminology of contact dermatitis","volume":"50","author":"Wilkinson D S","year":"1970","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03314.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12124"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161206778194079"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1396-0296.2004.04003.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12330"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000082570"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e3180db96ae"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb08403.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01325.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1046-199X(97)90092-0"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb00045.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2008.00442.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05666.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.6.749"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2007.06072"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12559","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T03:31:00Z","timestamp":1696303860000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,29]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/cod.12559"],"URL":"https:\/\/doi.org\/10.1111\/cod.12559","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,29]]}}}