{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T05:13:13Z","timestamp":1771564393553,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T00:00:00Z","timestamp":1459209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hair dyes represent one of the most important causes of allergic contact dermatitis resulting from the use of cosmetic products. The principal causative chemistry is associated with oxidation products of <jats:italic>p<\/jats:italic>\u2010phenylenediamine (<jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>) and closely related substances.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine whether prior application of the antioxidant vitamin C to the skin was able to reduce the cutaneous allergic response to <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty eight volunteers with a proven history of contact allergy to <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> were recruited. Each was tested with a range of <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> doses and <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>\u2010containing hair dye on untreated skin and skin pretreated for 10 min with a vitamin C formulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pretreatment of skin sites with vitamin C led to a reduction in the intensity, or even ablation, of the cutaneous allergic reaction to <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> in \u223c75% of cases as compared with untreated skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results suggest that treatment of the skin adjacent to the hair\u2010bearing area with antioxidant could form part of a strategy to reduce the burden of cosmetic allergic contact dermatitis caused by hair dyeing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12576","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T23:50:41Z","timestamp":1459381841000},"page":"368-372","source":"Crossref","is-referenced-by-count":19,"title":["Influence of vitamin C on the elicitation of allergic contact dermatitis to <i>p<\/i>\u2010phenylenediamine"],"prefix":"10.1111","volume":"74","author":[{"given":"David A.","family":"Basketter","sequence":"first","affiliation":[{"name":"HDS Ltd  Sharnbrook MK44 1PR UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian R.","family":"White","sequence":"additional","affiliation":[{"name":"HDS Ltd  Sharnbrook MK44 1PR UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preya","family":"Kullavanijaya","sequence":"additional","affiliation":[{"name":"Institute of Dermatology  Bangkok 10400 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