{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:57:48Z","timestamp":1790110668998,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,19]],"date-time":"2016-05-19T00:00:00Z","timestamp":1463616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Allergic contact dermatitis caused by p<\/jats:italic>\u2010phenylenediamine (PPD<\/jats:styled-content>) is common among all age groups and both sexes. Monitoring of prevalence and intensity of sensitization is important.<\/jats:p><\/jats:sec>Objective<\/jats:title>To evaluate contact allergy to PPD<\/jats:styled-content> in E<\/jats:styled-content>urope, and to compare reaction intensities in different E<\/jats:styled-content>uropean regions.<\/jats:p><\/jats:sec>Methods<\/jats:title>Data collected by the E<\/jats:styled-content>uropean S<\/jats:styled-content>urveillance S<\/jats:styled-content>ystem on C<\/jats:styled-content>ontact A<\/jats:styled-content>llergies (ESSCA<\/jats:styled-content>) network between 2002 and 2012 from 12 E<\/jats:styled-content>uropean countries were analysed regarding prevalence, grading of positive reactions to PPD<\/jats:styled-content>, and relevance.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 99\u2009926 PPD<\/jats:styled-content>\u2010positive patients from 63 departments were included for analysis. The overall (2002\u20132012) prevalence of PPD<\/jats:styled-content> sensitization in E<\/jats:styled-content>urope is \u223c4%. Stratified for country, the highest overall standardized prevalence was found in L<\/jats:styled-content>ithuania, and the lowest in S<\/jats:styled-content>lovenia. The prevalence of PPD<\/jats:styled-content> sensitization did not decline over the years. In the southern E<\/jats:styled-content>uropean countries, higher numbers of strong and extremely strong reactions were registered. The clinical relevance of PPD<\/jats:styled-content> sensitization varied from half to three\u2010quarters.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The prevalence of PPD<\/jats:styled-content> sensitization has not changed over time. Strong and extremely strong patch test reactions are seen more often in the S<\/jats:styled-content>outh, probably because of the higher number of PPD<\/jats:styled-content>\u2010containing hair dye products.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12583","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T14:15:08Z","timestamp":1463840108000},"page":"165-172","source":"Crossref","is-referenced-by-count":22,"title":["ESSCA<\/scp> results with the baseline series, 2002\u20132012: p<\/i>\u2010phenylenediamine"],"prefix":"10.1111","volume":"75","author":[{"given":"Marie\u2010Louise A.","family":"Schuttelaar","sequence":"first","affiliation":[{"name":"Dermatology, University Medical Center Groningen University of Groningen 9700 RB Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana A.","family":"Vogel","sequence":"additional","affiliation":[{"name":"Dermatology, University Medical Center Groningen University of Groningen 9700 RB Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Rui","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Clinical Unit of Occupational Medicine University of Trieste 34129 Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Kr\u0119cisz","sequence":"additional","affiliation":[{"name":"Faculty of Health Science Jan Kochanowski University 25\u2010317 Kielce Poland"},{"name":"Department of Dermatology Nofer Institute of Occupational Medicine 90\u2010950 Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Chomiczewska\u2010Skora","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nofer Institute of Occupational Medicine 90\u2010950 Lodz 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