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This essential oil is a popular remedy for many skin diseases, and may be used as neat oil or be present in cosmetics, topical pharmaceuticals and household products. Of all essential oils,<jats:styled-content style=\"fixed-case\">TTO<\/jats:styled-content>has caused most (published) allergic reactions since the first cases were reported in 1991. In routine testing, prevalences of positive patch test reactions have ranged from 0.1% to 3.5%. Nearly 100 allergic patients have been described in case reports and case series. The major constituents of commercial<jats:styled-content style=\"fixed-case\">TTO<\/jats:styled-content>are terpinen\u20104\u2010ol, \u03b3\u2010terpinene, 1,8\u2010cineole, \u03b1\u2010terpinene, \u03b1\u2010terpineol,<jats:italic>p\u2010<\/jats:italic>cymene, and \u03b1\u2010pinene. Fresh<jats:styled-content style=\"fixed-case\">TTO<\/jats:styled-content>is a weak to moderate sensitizer, but oxidation increases its allergenic potency. The major sensitizers appear to be ascaridole, terpinolene, \u03b1\u2010terpinene, 1,2,4\u2010trihydroxymenthane, \u03b1\u2010phellandrene, and limonene. The clinical picture of allergic contact dermatitis caused by<jats:styled-content style=\"fixed-case\">TTO<\/jats:styled-content>depends on the products used. Most reactions are caused by the application of pure oil; cosmetics are the culprits in a minority of cases. Patch testing may be performed with 5% oxidized<jats:styled-content style=\"fixed-case\">TTO<\/jats:styled-content>. Co\u2010reactivity to turpentine oil is frequent, and there is an overrepresentation of reactions to fragrance mix<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>,<jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>yroxylon pereirae<\/jats:italic>, colophonium, and other essential oils.<\/jats:p>","DOI":"10.1111\/cod.12591","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T11:08:43Z","timestamp":1463137723000},"page":"129-143","source":"Crossref","is-referenced-by-count":158,"title":["Tea tree oil: contact allergy and chemical composition"],"prefix":"10.1111","volume":"75","author":[{"given":"Anton C.","family":"de Groot","sequence":"first","affiliation":[{"name":"Acdegroot Publishing 8351 HV Wapserveen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich","family":"Schmidt","sequence":"additional","affiliation":[{"name":"86720 N\u00f6rdlingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1440-0960.1991.tb01788.x","article-title":"Contact dermatitis associated with the use of tea\u2010tree oil","volume":"32","author":"Apted J H","year":"1991","journal-title":"Australas J Dermatol"},{"key":"e_1_2_5_3_1","isbn-type":"print","volume-title":"Essential Oils: Contact Allergy and Cemical Ccomposition","author":"Groot A C","year":"2016","ISBN":"https:\/\/id.crossref.org\/isbn\/9781482246407"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/549510"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2013.08.006"},{"key":"e_1_2_5_6_1","first-page":"11","article-title":"Chemistry and biological activities of essential oils from Melaleuca L. species","volume":"78","author":"Almeida Barbosa L C","year":"2013","journal-title":"Agric Conspec Sci"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.19.1.50-62.2006"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202X.2004.22236.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.122734"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05654.x"},{"key":"e_1_2_5_11_1","unstructured":"Scientific Committee on Consumer products (SCCP). 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