{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:18Z","timestamp":1787014038742,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T00:00:00Z","timestamp":1468540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2017,3]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Irritant contact dermatitis is caused by skin barrier damage. Vitamin\n E<\/jats:styled-content>\n is an antioxidant that is commonly used in cosmetics to prevent photo\u2010damage.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To show the usefulness of reflectance confocal microscopy in the assessment of irritant skin damage caused by sodium lauryl sulfate (\n SLS<\/jats:styled-content>\n ) and of the protective action of vitamin\n E<\/jats:styled-content>\n applied prior to skin irritation.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Ten healthy volunteers were enrolled. Irritation was induced by the application of a patch test containing\n SLS<\/jats:styled-content>\n 5% aq. for 24\u2009h. Three sites were compared: one site on which a product with vitamin\n E<\/jats:styled-content>\n was applied before\n SLS<\/jats:styled-content>\n treatment, one site on which the same product was applied after\n SLS<\/jats:styled-content>\n treatment, and one control site (\n SLS<\/jats:styled-content>\n only). Each site was evaluated with reflectance confocal microscopy, providing\n in\u2009vivo<\/jats:italic>\n tissue images at nearly histological resolution. We also performed a computerized analysis of the\n V<\/jats:styled-content>\n iva\n S<\/jats:styled-content>\n tack\u00ae images.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Reflectance confocal microscopy is able to identify signs of skin irritation and the preventive effect of vitamin\n E<\/jats:styled-content>\n application.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Reflectance confocal microscopy is useful in the objective assessment of irritative skin damage.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cod.12613","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T02:58:00Z","timestamp":1468551480000},"page":"131-137","source":"Crossref","is-referenced-by-count":13,"title":["In\u2009vivo<\/i>\n assessment of cytological changes by means of reflectance confocal microscopy\u2009\u2013\u2009demonstration of the effect of topical vitamin\n E<\/scp>\n on skin irritation caused by sodium lauryl sulfate"],"prefix":"10.1111","volume":"76","author":[{"given":"Alice","family":"Casari","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Modena and Reggio Emilia 41125 Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Farnetani","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Modena and Reggio Emilia 41125 Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"De Pace","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Modena and Reggio Emilia 41125 Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Losi","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Modena and Reggio Emilia 41125 Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Christophe","family":"Pittet","sequence":"additional","affiliation":[{"name":"ORION Concept 37000 Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pellacani","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Modena and Reggio Emilia 41125 Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Skin Cancer Unit Arcispedale Santa Maria Nuova IRCCS 42100 Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2004.05765.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2001.110304.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1975.tb05434.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12319895"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2005.22100.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12364"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2012.06.012"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2011.00531.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2008.00443.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.11.1099"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.08.021"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2012.00623.x"},{"key":"e_1_2_5_14_1","first-page":"13","volume-title":"Diagnostica 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