{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:18:53Z","timestamp":1777533533611,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Contact allergy to linalool hydroperoxides (Lin\u2010<jats:styled-content style=\"fixed-case\">OOHs<\/jats:styled-content>) and limonene hydroperoxides (Lim\u2010<jats:styled-content style=\"fixed-case\">OOHs<\/jats:styled-content>) is common. Similarly to what occurs with the terpene hydroperoxides, reactive intermediates formed from <jats:italic>p<\/jats:italic>\u2010phenylenediamine (<jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>) can cause oxidative modifications of tryptophan residues on proteins in mechanistic studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To test the hypothesis that patients sensitized to <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> are at increased risk of concomitant reactivity to either of the terpene hydroperoxides, owing to a \u2018common pathway\u2019 of skin protein oxidation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A database study of consecutively patch tested eczema patients (n = 3843) from 2012 to 2015, tested concomitantly with <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>, Lim\u2010<jats:styled-content style=\"fixed-case\">OOHs<\/jats:styled-content> and Lin\u2010<jats:styled-content style=\"fixed-case\">OOHs<\/jats:styled-content>, was performed. Associations were examined by level of concordance and odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s) adjusted for age, sex, and contact allergy to fragrance mix I and fragrance mix <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Concomitant reactions to <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> were seen in 2.2% of Lim\u2010<jats:styled-content style=\"fixed-case\">OOH<\/jats:styled-content>\u2010positive patients and in 4.9% of Lin\u2010<jats:styled-content style=\"fixed-case\">OOH<\/jats:styled-content>\u2010positive patients. Neither proportion was higher than expected by chance. No association existed between <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> and Lim\u2010<jats:styled-content style=\"fixed-case\">OOH<\/jats:styled-content> patch test reactivity. In a multiple logistic regression analysis, <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> allergy was associated with an insignificantly increased risk (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.11, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>:0.92\u20134.80) of a positive patch test reaction to Lin\u2010<jats:styled-content style=\"fixed-case\">OOHs<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> sensitization cannot explain the high rates of sensitization to Lin\u2010<jats:styled-content style=\"fixed-case\">OOHs<\/jats:styled-content> and\/or Lim\u2010<jats:styled-content style=\"fixed-case\">OOHs<\/jats:styled-content>. Contact allergy to oxidized linalool is more strongly associated with fragrance allergy than with <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> allergy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12618","type":"journal-article","created":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T04:44:15Z","timestamp":1464842655000},"page":"67-73","source":"Crossref","is-referenced-by-count":5,"title":["Can contact allergy to <i>p<\/i>\u2010phenylenediamine explain the high rates of terpene hydroperoxide allergy? \u2013 An epidemiological study based on consecutive patch test results"],"prefix":"10.1111","volume":"76","author":[{"given":"Niels H\u00f8jsager","family":"Bennike","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010Allergology, National Allergy Research Centre, Herlev\u2010Gentofte Hospital University of Copenhagen  2900 Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Pierre","family":"Lepoittevin","sequence":"additional","affiliation":[{"name":"Dermatochemistry Laboratory, Institut de Chimie de Strasbourg University of Strasbourg  67081 Strasbourg cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology, National Allergy Research Centre, Herlev\u2010Gentofte Hospital University of Copenhagen  2900 Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"SCCS 2011: SCCS\/1459\/11Opinion on fragrance allergens in cosmetic products Adopted during the 13th plenary meeting 2012. 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