{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:57:30Z","timestamp":1790110650958,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T00:00:00Z","timestamp":1471996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2017,2]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Cross\u2010reactions and co\u2010sensitizations are of great importance in understanding contact allergy and exposure sources.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To investigate common cross\u2010reactions and co\u2010sensitizations in p<\/jats:italic>\u2010<\/jats:italic>phenylenediamine (PPD<\/jats:styled-content>)\u2010sensitized and toluene\u20102,5\u2010diamine (TDA<\/jats:styled-content>)\u2010sensitized individuals.<\/jats:p><\/jats:sec>Methods<\/jats:title>From our patch test population, 8036 patients patch tested with the European baseline series were extracted. Readings had to be performed at least on day 3 according to ICDRG<\/jats:styled-content> guidelines.<\/jats:p><\/jats:sec>Results<\/jats:title>Two hundred and fifty\u2010one patients were sensitized to PPD<\/jats:styled-content> and\/or TDA<\/jats:styled-content>; 231 patients were sensitized to PPD<\/jats:styled-content>, and 109 to TDA<\/jats:styled-content>. Significant differences were observed regarding the strengths of patch test reactions to PPD<\/jats:styled-content> and number of cross\u2010reactions. For TDA<\/jats:styled-content>, a difference was found between all reaction strengths, except between + and ++ strengths. PPD<\/jats:styled-content>\u2010sensitized individuals were more likely to be sensitized to carba mix, cobalt chloride, colophonium, p<\/jats:italic>\u2010tert<\/jats:italic>\u2010butyl phenolformaldehyde resin, paraben mix, and methylisothiazolinone. TDA<\/jats:styled-content>\u2010sensitized individuals were more often sensitized to carba mix.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Cross\u2010reactivity was commonly found among individuals sensitized to PPD<\/jats:styled-content> or TDA<\/jats:styled-content>, and was strongly related to the strength of the patch test reaction. Regarding co\u2010sensitizations, a frequently appearing or common exposure source could not be determined. However, modification of the allergen by, for example, the skin microbiota may have caused the formation of molecules that are, for the human immune system, indistinguishable from PPD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12619","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T07:16:37Z","timestamp":1472022997000},"page":"81-88","source":"Crossref","is-referenced-by-count":31,"title":["Two decades of p<\/i>\u2010phenylenediamine and toluene\u20102,5\u2010diamine patch testing \u2013 focus on co\u2010sensitizations in the European baseline series and cross\u2010reactions with chemically related substances"],"prefix":"10.1111","volume":"76","author":[{"given":"Tatiana A.","family":"Vogel","sequence":"first","affiliation":[{"name":"Department of Dermatology University Medical Center Groningen, University of Groningen Groningen 9700 RB The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakita W.","family":"Heijnen","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center Groningen, University of Groningen Groningen 9700 RB The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter\u2010Jan","family":"Coenraads","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center Groningen, University of Groningen Groningen 9700 RB The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Louise","family":"Schuttelaar","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center Groningen, University of Groningen Groningen 9700 RB The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2310\/6620.2009.08089","article-title":"Consumer allergy to oxidative hair coloring products: epidemiologic data in the literature","volume":"20","author":"Krasteva M","year":"2009","journal-title":"Dermatitis"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12354"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2015.10.064"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1988.tb02921.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12255"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12077"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/15569520902940335"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1992.tb05215.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2002.1o3314.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1995.tb00748.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2006.06026"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01968.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08644.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01091.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1984.tb00928.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408419209114557"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1191\/096032799678845061"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12619","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12619","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T03:38:21Z","timestamp":1696304301000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,24]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/cod.12619"],"URL":"https:\/\/doi.org\/10.1111\/cod.12619","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,24]]}}}