{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T03:21:07Z","timestamp":1771039267244,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T00:00:00Z","timestamp":1467158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Measures to prevent occupational exposure to epoxy resins, including education, medical examination, and voluntary agreements between employers and workers, have not been effective enough to protect against skin sensitization. Therefore, alternatives to the major epoxy resin haptens that have been found to be less sensitizing in the local lymph node assay have been developed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To study the cross\u2010reactivity of two newly designed epoxy resin monomers, with decreased skin\u2010sensitizing potency and good technical properties as compared with diglycidyl ether of bisphenol <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">DGEBA<\/jats:styled-content>), in subjects with known contact allergy to epoxy resin of <jats:styled-content style=\"fixed-case\">DGEBA<\/jats:styled-content> type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Eleven individuals with previous positive patch test reactions to epoxy resin of <jats:styled-content style=\"fixed-case\">DGEBA<\/jats:styled-content> participated in the study. The two alternative epoxy resin monomers were synthesized and patch tested in dilution series in parallel with epoxy resin of <jats:styled-content style=\"fixed-case\">DGEBA<\/jats:styled-content> from the baseline series (containing 92% <jats:styled-content style=\"fixed-case\">DGEBA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All participants reacted to epoxy resin of <jats:styled-content style=\"fixed-case\">DGEBA<\/jats:styled-content> on retesting. Three participants reacted to monomer 1. No reactions were seen to monomer 2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The alternative monomers studied showed little or no cross\u2010reactivity with epoxy resin of <jats:styled-content style=\"fixed-case\">DGEBA<\/jats:styled-content>. Decreasing the risk of sensitization by using less sensitizing compounds is important, as contact allergy to epoxy resins is common in spite of thorough preventive measures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12624","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T18:46:30Z","timestamp":1467225990000},"page":"144-150","source":"Crossref","is-referenced-by-count":16,"title":["Assessment of cross\u2010reactivity of new less sensitizing epoxy resin monomers in epoxy resin\u2010allergic individuals"],"prefix":"10.1111","volume":"75","author":[{"given":"Lina","family":"Hagvall","sequence":"first","affiliation":[{"name":"Department of Dermatology Sahlgrenska Academy at the University of Gothenburg  405 03 Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida B.","family":"Niklasson","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Molecular Biology, Dermatochemistry University of Gothenburg  412 96 Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Rudb\u00e4ck","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Molecular Biology, Dermatochemistry University of Gothenburg  412 96 Gothenburg Sweden"},{"name":"Department of Radiology and Medicine Laboratory, Clinical Chemistry S\u00f6dra \u00c4lvsborg Hospital  501 82 Bor\u00e5s Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niamh M.","family":"O'Boyle","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Molecular Biology, Dermatochemistry University of Gothenburg  412 96 Gothenburg Sweden"},{"name":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Niklasson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sahlgrenska Academy at the University of Gothenburg  405 03 Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Luthman","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Molecular Biology, Medicinal Chemistry University of Gothenburg  412 96 Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann\u2010Therese","family":"Karlberg","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Molecular Biology, Dermatochemistry University of Gothenburg  412 96 Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02072.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.02028.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-010-0581-8"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx900193s"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx100417r"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx300305k"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx5000624"},{"key":"e_1_2_6_9_1","first-page":"559","volume-title":"Occupational Skin Diseases","author":"Nixon R","year":"2012"},{"key":"e_1_2_6_10_1","first-page":"1","volume-title":"Epoxy Resins. 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