{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T03:15:28Z","timestamp":1771038928799,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T00:00:00Z","timestamp":1471996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Amines in epoxy hardeners are significant causes of occupational allergic contact dermatitis among workers who use epoxy resin systems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe a novel group of contact allergens: <jats:italic><jats:styled-content style=\"fixed-case\">N<\/jats:styled-content><\/jats:italic>\u2010(2\u2010phenylethyl) derivatives of the reactive amine 1,3\u2010benzenedimethanamine (1,3\u2010<jats:styled-content style=\"fixed-case\">BDMA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We describe the clinical examinations and exposure of 6 patients with occupational contact allergy to derivatives of 1,3\u2010<jats:styled-content style=\"fixed-case\">BDMA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 6 patients, 4 were spray painters who used epoxy paints, 1 was a floor layer who handled a variety of epoxy coatings, and 1 was a worker in epoxy hardener manufacture. We were able to confirm exposure to epoxy hardeners that contained derivatives of 1,3\u2010<jats:styled-content style=\"fixed-case\">BDMA<\/jats:styled-content> in 5 of the 6 sensitized patients. Despite the close structural resemblance between derivatives of 1,3\u2010<jats:styled-content style=\"fixed-case\">BDMA<\/jats:styled-content> and <jats:italic>m<\/jats:italic>\u2010xylylenediamine (<jats:styled-content style=\"fixed-case\">MXDA<\/jats:styled-content>), only 3 patients reacted positively to <jats:styled-content style=\"fixed-case\">MXDA<\/jats:styled-content>. Concomitant contact allergy to diglycidyl ether of bisphenol <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> resin was seen in 2 of the 6 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Because of the lack of a commercially available patch test substance, the diagnosis of contact allergy to derivatives of 1,3\u2010<jats:styled-content style=\"fixed-case\">BDMA<\/jats:styled-content> requires patch testing with either the epoxy hardener product or a hardener ingredient that contains the derivatives of 1,3\u2010<jats:styled-content style=\"fixed-case\">BDMA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12652","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T07:22:53Z","timestamp":1472023373000},"page":"358-362","source":"Crossref","is-referenced-by-count":18,"title":["Occupational contact dermatitis caused by 1,3\u2010benzenedimethanamine, <i><scp>N<\/scp><\/i>\u2010(2\u2010phenylethyl) derivatives in hardeners for epoxy paints and coatings"],"prefix":"10.1111","volume":"75","author":[{"given":"Maria","family":"Pesonen","sequence":"first","affiliation":[{"name":"Occupational Medicine Finnish Institute of Occupational Health (FIOH)  Helsinki 00251 Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Outi","family":"Kuuliala","sequence":"additional","affiliation":[{"name":"Occupational Medicine Finnish Institute of Occupational Health (FIOH)  Helsinki 00251 Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sari","family":"Suomela","sequence":"additional","affiliation":[{"name":"Occupational Medicine Finnish Institute of Occupational Health (FIOH)  Helsinki 00251 Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristiina","family":"Aalto\u2010Korte","sequence":"additional","affiliation":[{"name":"Occupational Medicine Finnish Institute of Occupational Health (FIOH)  Helsinki 00251 Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,24]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"156","volume-title":"Ullmann's Encyclopedia of Industrial Chemistry","author":"Pham H Q","year":"2012"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12333"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12445"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-02035-3_51"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01634989-199106000-00004"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12280"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12491"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01197.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-02035-3_51"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1979.tb04920.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12455"},{"key":"e_1_2_5_14_1","unstructured":"ECHA registration Dossier 4140: 1 3\u2010Benzenedimethanamine N\u2010(2\u2010phenylethyl) derivs. Available at:http:\/\/echa.europa.eu\/en\/registration\u2010dossier\/\u2010\/registered\u2010dossier\/4140(last accessed 27 May 2016)."},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12475"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12652","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12652","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T10:45:22Z","timestamp":1696329922000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,24]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1111\/cod.12652"],"URL":"https:\/\/doi.org\/10.1111\/cod.12652","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,24]]}}}