{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:23:02Z","timestamp":1772223782187,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T00:00:00Z","timestamp":1477008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2017,1]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n In 2014, the fragrance hydroxyisohexyl 3\u2010cyclohexene carboxaldehyde (HICC) was excluded from the Swedish baseline series.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To study (i) whether fragrance mix (\n FM<\/jats:styled-content>\n )\n II<\/jats:styled-content>\n with 5% HICC detects more positive reactions than usual\n FM II<\/jats:styled-content>\n with 2.5%\n HICC<\/jats:styled-content>\n , and (ii) the reproducibility of patch testing with\n HICC<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Two thousand one hundred and eighteen dermatitis patients at five\n S<\/jats:styled-content>\n wedish dermatology departments were consecutively tested with\n FM II<\/jats:styled-content>\n 14% pet.,\n FM II<\/jats:styled-content>\n 16.5% pet., and duplicate preparations of\n HICC<\/jats:styled-content>\n 5% pet.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the patients, 3.2% reacted to\n FM II<\/jats:styled-content>\n 14%, and 1.5% reacted to\n HICC<\/jats:styled-content>\n . Separate testing with\n HICC<\/jats:styled-content>\n detected 0.3% reactions without concomitant reactivity to\n FM II<\/jats:styled-content>\n .\n FM II<\/jats:styled-content>\n with 5%\n HICC<\/jats:styled-content>\n did not give rise to more irritant reactions or signs of active sensitization than\n FM II<\/jats:styled-content>\n with 2.5%\n HICC<\/jats:styled-content>\n . Patch testing with duplicate applications of\n HICC<\/jats:styled-content>\n increased the overall prevalence of\n HICC<\/jats:styled-content>\n contact allergy to 1.9%.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n FM II<\/jats:styled-content>\n with 5%\n HICC<\/jats:styled-content>\n does not detect more positive reactions than\n FM II<\/jats:styled-content>\n with 2.5%\n HICC<\/jats:styled-content>\n . Separate testing with\n HICC<\/jats:styled-content>\n does not detect a sufficient proportion of patients who react only to\n HICC<\/jats:styled-content>\n , without concomitant reactions to\n FM II<\/jats:styled-content>\n , to warrant its inclusion in a baseline series.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cod.12699","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T05:16:53Z","timestamp":1477027013000},"page":"34-39","source":"Crossref","is-referenced-by-count":17,"title":["Patch testing with hydroxyisohexyl 3\u2010cyclohexene carboxaldehyde (\n HICC<\/scp>\n )\u00a0\u2013\u00a0a multicentre study of the\n S<\/scp>\n wedish\n C<\/scp>\n ontact\n D<\/scp>\n ermatitis\n R<\/scp>\n esearch\n G<\/scp>\n roup"],"prefix":"10.1111","volume":"76","author":[{"given":"Malin","family":"Engfeldt","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital 205 02 Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Hagvall","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sahlgrenska University Hospital 413 45 Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marl\u00e9ne","family":"Isaksson","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital 205 02 Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mih\u00e1ly","family":"Matura","sequence":"additional","affiliation":[{"name":"Unit of Occupational and Environmental Dermatology Institute of Environmental Medicine, Karolinska Institute and Centre for Occupational and Environmental Medicine 113 65 Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Mowitz","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital 205 02 Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Ryberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology Uddevalla Hospital 451 80 Uddevalla Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berndt","family":"Stenberg","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, Dermatology & Venerology Ume\u00e5 University 901 85 Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Svedman","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital 205 02 Malm\u00f6 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