{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:27:27Z","timestamp":1790202447234,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T00:00:00Z","timestamp":1476835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Mersin University Department of Scientific Research","award":["BAP-SBE EMBB (AA) 2013-3YL"],"award-info":[{"award-number":["BAP-SBE EMBB (AA) 2013-3YL"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Henna has a very low allergic potential, and severe allergenic contact dermatitis is mainly caused by\n                      <jats:italic>p<\/jats:italic>\n                      \u2010phenylenediamine (\n                      <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>\n                      ), which is added to temporary black \u2018henna tattoos\u2019, and potentially also by some heavy metals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To determine the presence of, and quantify, Lawsone,\n                      <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>\n                      and heavy metal contaminants (cobalt, nickel, lead, and chromium) in commercial temporary black henna tattoo mixtures (n = 25) sold in Turkey.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Lawsone and\n                      <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>\n                      concentrations were analysed with high\u2010performance liquid chromatography, and heavy metal quantification was performed with inductively coupled plasma mass spectrometry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>\n                      was found in all 25 black henna tattoo samples purchased from tattoo shops; levels varied between 3.37% and 51.6%. Lawsone was detected (0.002\u201388.2%) in 21 of the 25 temporary black henna tattoo samples analysed. Heavy metal contaminant levels were 0.44\u20133.11 ppm for Co, 1.13\u20132.20 ppm for Ni, 1.59\u201317.7 ppm for Pb, and 35.0\u201376.9 ppm for Cr.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our results suggest that commercial temporary black henna mixtures containing\n                      <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>\n                      levels up to 51.6% pose a risk of contact sensitization and severe allergic contact dermatitis among users. It is important to identify both the additives and metallic contaminants of black henna tattoo products; the significance of metal contaminants has still to be assessed.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.12702","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T02:32:48Z","timestamp":1476844368000},"page":"89-95","source":"Crossref","is-referenced-by-count":27,"title":["Monitoring of Lawsone,\n                    <i>p<\/i>\n                    \u2010phenylenediamine and heavy metals in commercial temporary black henna tattoos sold in Turkey"],"prefix":"10.1111","volume":"76","author":[{"given":"Ayca","family":"Aktas Sukuroglu","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Department of Toxicology Mersin University  33169 Mersin Turkey"},{"name":"Faculty of Pharmacy, Department of Toxicology Gazi University  06330 Ankara 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