{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T12:20:28Z","timestamp":1776946828975,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T00:00:00Z","timestamp":1480377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Limonene and linalool are common fragrance terpenes widely used in cosmetic, household and hygiene products. Their primary oxidation products formed after air exposure, the hydroperoxides, have been recognized as important contact haptens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the prevalence of contact allergy to hydroperoxides of limonene (Lim\u2010OOHs) and hydroperoxides of linalool (Lin\u2010OOHs) in Spain, and to define the optimal concentration for screening in consecutive patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three different concentrations of Lim\u2010OOHs (0.1%, 0.2% and 0.3% pet.) and Lin\u2010OOHs (0.25%, 0.5% and 1.0% pet.) were simultaneously tested in 3639 consecutive patients at 22 departments of dermatology in Spain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lim\u2010OOHs at 0.1%, 0.2% and 0.3% yielded positive patch test reactions in 1.4%, 3.4% and 5.1% of the tested patients, respectively; and Lin\u2010OOHs at 0.25%, 0.5% and 1.0% yielded positive reactions in 1.3%, 2.9% and 4.9% of the tested patients, respectively. Few irritant (1.5\u20131.9%) and doubtful reactions (0.4\u20130.5%) to both terpene hydroperoxides were registered at the highest concentrations tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lim\u2010OOHs and Lin\u2010OOHs can be considered as common causes of contact allergy, and their inclusion in an extended baseline patch test series therefore seems to be appropriate. The patch test preparations of Lim\u2010OOHs 0.3% pet. and Lin\u2010OOHs 1.0% pet. are useful tools for screening of contact sensitization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12714","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T06:42:45Z","timestamp":1480401765000},"page":"74-80","source":"Crossref","is-referenced-by-count":67,"title":["Contact sensitization to limonene and linalool hydroperoxides in Spain: a GEIDAC<sup>*<\/sup> prospective study"],"prefix":"10.1111","volume":"76","author":[{"given":"Gustavo","family":"Deza","sequence":"first","affiliation":[{"name":"Department of Dermatology, Hospital del Mar, Institut Mar d'Investigacions M\u00e8diques Universitat Aut\u00f2noma de Barcelona (UAB)  08003 Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bego\u00f1a","family":"Garc\u00eda\u2010Bravo","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Virgen Macarena  41009 Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan F.","family":"Silvestre","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Alicante, Instituto de Investigaci\u00f3n Sanitaria y Biom\u00e9dica de Alicante\u2010 Fundaci\u00f3n FISABIO  03010 Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Pastor\u2010Nieto","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Guadalajara  19002 Guadalajara Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Gonz\u00e1lez\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Araba  01009 Vitoria Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Heras\u2010Mendaza","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fundaci\u00f3n Jim\u00e9nez D\u00edaz  28040 Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Mercader","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Morales Meseguer  30008 Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Fern\u00e1ndez\u2010Redondo","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Santiago de Compostela  15706 Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Niklasson","sequence":"additional","affiliation":[{"name":"Chemotechnique Diagnostics  235 39 Vellinge Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana M.","family":"Gim\u00e9nez\u2010Arnau","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hospital del Mar, Institut Mar d'Investigacions M\u00e8diques 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