{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:33:36Z","timestamp":1791405216108,"version":"4.3.3"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T00:00:00Z","timestamp":1479772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008271","name":"LEO Pharma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Skin\u2010resident memory T (T\n                      <jats:sub>RM<\/jats:sub>\n                      ) cells are associated with immunological memory in the skin. Whether immunological memory responses to allergens in the skin are solely localized to previously allergen\u2010exposed sites or are present globally in the skin is not clear. Furthermore, the mechanisms whereby T\n                      <jats:sub>RM<\/jats:sub>\n                      cells induce rapid recall responses need further investigation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To study whether contact allergens induce local and\/or global memory, and to determine the mechanisms involved in memory responses in the skin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To address these questions, we analysed responses to contact allergens in mice and humans sensitized to 2,4\u2010dinitrofluorobenzene and nickel, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Challenge responses in both mice and humans were dramatically increased at sites previously exposed to allergens as compared with previously unexposed sites. Importantly, the magnitude of the challenge response correlated with the epidermal accumulation of interleukin (IL)\u201017A\u2010producing and interferon (IFN)\u2010\u03b3\u2010producing T\n                      <jats:sub>RM<\/jats:sub>\n                      cells. Moreover, IL\u201017A and IFN\u2010\u03b3 enhanced allergen\u2010induced IL\u20101\u03b2 production in keratinocytes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      We show that sensitization with contact allergens induces a strong, long\u2010lasting local memory and a weaker, temporary global immunological memory response to the allergen that is mediated by IL\u201017A\u2010producing and IFN\u2010\u03b3\u2010producing CD8\n                      <jats:sup>+<\/jats:sup>\n                      T\n                      <jats:sub>RM<\/jats:sub>\n                      cells.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.12715","type":"journal-article","created":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T02:36:43Z","timestamp":1479782203000},"page":"218-227","source":"Crossref","is-referenced-by-count":90,"title":["Rapid allergen\u2010induced interleukin\u201017 and interferon\u2010\u03b3 secretion by skin\u2010resident memory CD8\n                    <sup>+<\/sup>\n                    T cells"],"prefix":"10.1111","volume":"76","author":[{"given":"Jonas D.","family":"Schmidt","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbiology, Faculty of Health and Medical Sciences University of Copenhagen  2200 Copenhagen Denmark"},{"name":"Department of Dermato\u2010Allergology, National Allergy Research Centre Copenhagen University Hospital Gentofte  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin G.","family":"Ahlstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of 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