{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T13:44:23Z","timestamp":1787233463894,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T00:00:00Z","timestamp":1480636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2017,4]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n As in contact allergy,\n T<\/jats:styled-content>\n cell\u2010mediated hypersensitivity in non\u2010immediate (\n NI<\/jats:styled-content>\n ) cutaneous adverse drug reactions (\n CADR<\/jats:styled-content>\n s) to antibiotics is considered to be lifelong, but, in this setting, patch tests have rarely been repeated after long time intervals.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To evaluate the long\u2010term reproducibility of positive patch test reactions to antibiotics in patients with\n NI CADR<\/jats:styled-content>\n s.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Fifty\u2010six patients with\n NI CADR<\/jats:styled-content>\n s to antibiotics who had relevant positive reactions during patch testing were invited to repeat patch tests with a similar antibiotic series 2\u201315 years thereafter.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Twenty patients were included (9 males and 11 females; mean age 54.6 years): 18 with maculopapular exanthema, 1 with drug hypersensitivity syndrome, and 1 with acute generalized exanthematous pustulosis. Results were reproducible in 17 of 20 patients after a mean interval of 6.0 years (range 2\u201314.7 years). Concerning \u03b2\u2010lactams, 7 of 8 patients remained positive for aminopenicillins, 4 of 4 for isoxazolyl penicillins, and 1 for cefoxitin. Patch test results were also reproducible for clindamycin in 5 of 7 patients, for vancomycin in 1 patient, and for spiramycin in 1 patient. Reproducibility was not affected by the time interval between tests, sex, or age at testing.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In the context of\n NI CADR<\/jats:styled-content>\n s, we showed high reproducibility of positive patch test reactions to various antibiotics, even after several years.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cod.12720","type":"journal-article","created":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T01:53:13Z","timestamp":1480643593000},"page":"204-209","source":"Crossref","is-referenced-by-count":35,"title":["Long\u2010term reproducibility of positive patch test reactions in patients with non\u2010immediate cutaneous adverse drug reactions to antibiotics"],"prefix":"10.1111","volume":"76","author":[{"given":"Andr\u00e9","family":"Pinho","sequence":"first","affiliation":[{"name":"Dermatology Department Hospitais da Universidade de Coimbra, Centro Hospitalar e Universit\u00e1rio de Coimbra 3000\u2010045 Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Marta","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Clinic of Dermatology University of Coimbra 3000\u2010045 Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospitais da Universidade de Coimbra, Centro Hospitalar e Universit\u00e1rio de Coimbra 3000\u2010045 Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida","family":"Gon\u00e7alo","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospitais da Universidade de Coimbra, Centro Hospitalar e Universit\u00e1rio de Coimbra 3000\u2010045 Coimbra Portugal"},{"name":"Faculty of Medicine, Clinic of Dermatology University of Coimbra 3000\u2010045 Coimbra 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