{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:00:42Z","timestamp":1785855642242,"version":"3.56.0"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R108\u2010A10225"],"award-info":[{"award-number":["R108\u2010A10225"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Information concerning health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQoL<\/jats:styled-content>) and comorbidities of adult dermatitis patients stratified by loss\u2010of\u2010function mutations in the filaggrin gene (<jats:italic><jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content><\/jats:italic>) is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate HRQoL, skin symptoms and comorbidities in adult <jats:italic>FLG<\/jats:italic> mutation carriers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study included patients diagnosed with atopic dermatitis and\/or hand eczema (n\u2009=\u2009520). Patients completed questionnaires about dermatitis, skin symptoms, <jats:styled-content style=\"fixed-case\">HRQoL<\/jats:styled-content>, and comorbidities, including actinic keratosis, and atopic and mental disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic><jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content><\/jats:italic> mutations (<jats:styled-content style=\"fixed-case\">R501X<\/jats:styled-content>, 2282del4, and <jats:styled-content style=\"fixed-case\">R2447X<\/jats:styled-content>) were identified in 16.9% of patients, and were significantly associated not only with atopic dermatitis, but also independently with skin fissures on the fingers and heels, and self\u2010reported actinic keratosis. Although <jats:italic><jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content><\/jats:italic> mutations were significantly associated with reduced <jats:styled-content style=\"fixed-case\">HRQoL<\/jats:styled-content>, as measured by use of the <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ermatology <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ife <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uality <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndex (<jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content>), no association with self\u2010reported anxiety or depression was identified. Notably, the highest median <jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content> score, reflecting greater impairment, was reported by patients with both <jats:italic><jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content><\/jats:italic> mutations and atopic dermatitis. Overall, 19.7% of patients with both atopic dermatitis and <jats:italic><jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content><\/jats:italic> mutations reported a \u2018large or extremely large\u2019 impact on their lives; this represents twice the prevalence seen in patients with atopic dermatitis and wild\u2010type <jats:italic><jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content><\/jats:italic> (9.6%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with both atopic dermatitis and common <jats:italic><jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content><\/jats:italic> mutations are more frequently affected by reduced <jats:styled-content style=\"fixed-case\">HRQoL<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12731","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T08:56:49Z","timestamp":1482224209000},"page":"167-177","source":"Crossref","is-referenced-by-count":23,"title":["Health\u2010related quality of life in adult dermatitis patients stratified by filaggrin genotype"],"prefix":"10.1111","volume":"76","author":[{"given":"Nina G.","family":"Heede","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy, The National Allergy Research Centre Copenhagen University Hospital Herlev\u2010Gentofte  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob P.","family":"Thyssen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, The National Allergy Research Centre Copenhagen University Hospital Herlev\u2010Gentofte  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betina H.","family":"Thuesen","sequence":"additional","affiliation":[{"name":"Research Centre for Prevention and Health, the Capital Region of Denmark  2600 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Linneberg","sequence":"additional","affiliation":[{"name":"Research Centre for Prevention and Health, the Capital Region of Denmark  2600 Copenhagen Denmark"},{"name":"Department of Clinical Experimental Research Rigshospitalet  Glostrup Denmark"},{"name":"Faculty of Health and Medical Sciences, Department of Clinical Medicine University of Copenhagen  2200 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pal B.","family":"Szecsi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital Herlev\u2010Gentofte  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen","family":"Stender","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital Herlev\u2010Gentofte  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, The National Allergy Research Centre Copenhagen University Hospital Herlev\u2010Gentofte  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1767"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8561(03)00066-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.d01-926.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.10271"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.5432"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.05.003"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.337"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2011.01295.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.07050.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.03.036"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.02.014"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2433"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.01.031"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.450604.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.01.001"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01362.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01305.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14167"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.2340\/0001555571296300","article-title":"Susceptibility of atopic dermatitis patients to irritant dermatitis caused by sodium lauryl sulphate","volume":"71","author":"Agner T","year":"1991","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13651"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12464"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12083"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09245.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09822.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12139"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14215"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb02435.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2012.06.014"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2020"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011040"},{"key":"e_1_2_6_34_1","volume-title":"EpiData Entry (Version 1.4.4.4). A Comprehensive Tool for Validated Entry and Documentation of Data","author":"Lauritsen J M","year":"2015"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09708.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14476"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(85)90021-8"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.47.2.76"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)80041-3"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8510(90)90421-9"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10530.x"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09339.x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.324"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.01.013"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(82)90314-2"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.1996.tb00183.x"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.231"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/372773a0"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03541.x"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13883"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12731","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12731","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:38:29Z","timestamp":1696293509000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,20]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/cod.12731"],"URL":"https:\/\/doi.org\/10.1111\/cod.12731","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,20]]}}}