{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:03:28Z","timestamp":1790539408966,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T00:00:00Z","timestamp":1482883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"EADV","award":["2015-015"],"award-info":[{"award-number":["2015-015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2017,5]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>The use of methylisothiazolinone (MI<\/jats:styled-content>) in cosmetic products has caused an unprecedented epidemic of MI<\/jats:styled-content> contact allergy. Current data concerning exposures at a E<\/jats:styled-content>uropean level are required.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To describe demographics and MI<\/jats:styled-content> exposures for E<\/jats:styled-content>uropean patients with MI<\/jats:styled-content> contact allergy.<\/jats:p><\/jats:sec>Methods<\/jats:title>Eleven E<\/jats:styled-content>uropean dermatology departments from eight E<\/jats:styled-content>uropean countries prospectively collected data between 1 M<\/jats:styled-content>ay and 31 O<\/jats:styled-content>ctober 2015 among consecutive patients who had positive patch test reactions to MI<\/jats:styled-content> (2000\u2009ppm aq.).<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 6.0% (205\/3434; range 2.6\u201313.0%) of patients had positive patch test reactions to MI<\/jats:styled-content>. Dermatitis most frequently affected the hands (43.4%), face (32.7%), arms (14.6%), and eyelids (11.7%); 12.7% had widespread dermatitis. For 72.7% (149\/205), MI<\/jats:styled-content> contact allergy was currently relevant mainly because of exposure to cosmetic products (83.2%; 124\/149). Of these 124 patients, 19.5% were exposed to leave\u2010on and rinse\u2010off cosmetic products, 24.8% only to leave\u2010on cosmetic products and 38.9% only to rinse\u2010off cosmetic products containing MI<\/jats:styled-content> or methylchloroisothiazolinone\/MI<\/jats:styled-content>. The majority of these (79%) noted onset of their dermatitis between 2013 and 2015. Fifteen patients (7.3%) had previously experienced allergic reactions when they were in newly painted rooms.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Clinically relevant MI<\/jats:styled-content> contact allergy remains prevalent across E<\/jats:styled-content>uropean countries, mainly because of exposure to rinse\u2010off and leave\u2010on cosmetic products.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12733","type":"journal-article","created":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T04:42:42Z","timestamp":1482986562000},"page":"272-279","source":"Crossref","is-referenced-by-count":93,"title":["The epidemic of methylisothiazolinone: a E<\/scp>uropean prospective study"],"prefix":"10.1111","volume":"76","author":[{"given":"Jakob F.","family":"Schwensen","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010Allergology, National Allergy Research Centre, Gentofte Hospital University of Copenhagen 2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Uter","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Biometry and Epidemiology University of Erlangen\/N\u00fcrnberg 91054 Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital 205\u200902 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Svedman","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital 205\u200902 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Goossens","sequence":"additional","affiliation":[{"name":"Contact Allergy Unit, Department of Dermatology University Hospital KU Leuven 3000 Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Department of dermatology, Leeds Teaching Hospitals NHS Trust Leeds LS7 4SA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Gim\u00e9nez Arnau","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hospital del Mar Universitat Aut\u00f2noma de Barcelona 08003 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida","family":"Gon\u00e7alo","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital and Faculty of Medicine, University of Coimbra 3000\u2010075 Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus E.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital, University of Southern Denmark 5000 Odense Denmark"},{"name":"Centre for Innovative Medical Technology, Institute of Clinical Research Odense University Hospital, University of Southern Denmark 5000 Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evy","family":"Paulsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital, University of Southern Denmark 5000 Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tove","family":"Agner","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Copenhagen, Bispebjerg Hospital 2400 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Foti","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, Department of Biomedical Science and Human Oncology University of Bari 70124 Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristiina","family":"Aalto\u2010Korte","sequence":"additional","affiliation":[{"name":"Occupational Medicine Finnish Institute of Occupational Health 00250 Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"McFadden","sequence":"additional","affiliation":[{"name":"St John's Institute of Dermatology St Thomas' Hospital London SE1 7EH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"White","sequence":"additional","affiliation":[{"name":"St John's Institute of Dermatology St Thomas' Hospital London SE1 7EH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology, National Allergy Research Centre, Gentofte Hospital University of Copenhagen 2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the European Environmental Contact Dermatitis Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2340\/0001555567315320","article-title":"Contact allergy to the active ingredients of Kathon CG in the guinea pig","volume":"67","author":"Bruze M","year":"1987","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1987.tb01421.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2004.04017"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01754.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12249"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12200"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02157.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12207"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12185"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12186"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12217"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12446"},{"key":"e_1_2_6_14_1","first-page":"334","article-title":"Risk factors associated with methylisothiazolinone contact sensitization","volume":"69","author":"Uter W","year":"2013","journal-title":"Contact Dermatitis"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12235"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/es500236m"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12068"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12322"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12379"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12098"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12416"},{"key":"e_1_2_6_22_1","unstructured":"Scientific Committee on Consumer Safety (SCCS).Opinion on methylisothiazolinone (P94)\u2009\u2013\u2009Submission II (sensitisation only). SCCS\/1521\/13 2014March 27. Available at:http:\/\/ec.europa.eu\/health\/scientific_committees\/consumer_safety\/docs\/sccs_o_145.pdf(last accessed 11 October 2016)."},{"key":"e_1_2_6_23_1","unstructured":"Scientific Committee on Consumer Safety (SCCS).Opinion on methylisothiazolinone (P94)\u2009\u2013\u2009Submission III. SCCS\/1557\/15 2015December 15. Available at:http:\/\/ec.europa.eu\/health\/scientific_committees\/consumer_safety\/docs\/sccs_o_178.pdf(last accessed 11 October 2016)."},{"key":"e_1_2_6_24_1","unstructured":"European Commission (EC). Directorate General for Internal Market Industry Entrepreneurship and SMEs.Public consultation on Methylisothiazolinone (MI) in the framework of Regulation (EC) No. 1223\/209\u2009\u2013\u2009rinse\u2010off cosmetic products 01\/04\/2016. Available at:http:\/\/ec.europa.eu\/growth\/tools\u2010databases\/newsroom\/cf\/itemdetail.cfm?item_id=8740&lang=en&title=Public\u2010consultation\u2010on\u2010Methylisothiazolinone\u20108MI9\u2010in\u2010the\u2010framework\u2010of\u2010Regulation\u2010EC9\u2010NoE\u20101223F2009\u2010\u2010rinse\u2010off\u2010cosmetic\u2010products(last accessed 11 October 2016)."},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00406.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12403"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13751"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12149"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01828.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12165"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12219"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02012.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12136"},{"key":"e_1_2_6_35_1","unstructured":"European Chemicals Agency (ECHA).Guidance on labelling and packaging in accordance with regulation (EC) No. 1272\/2008 Reference ECHA\u201011\u2010G\u201004\u2010EN2011April. Available at:https:\/\/echa.europa.eu\/documents\/10162\/13562\/clp_labelling_en.pdf(last accessed 11 October 2016)."},{"key":"e_1_2_6_36_1","unstructured":"European Chemicals Agency (ECHA).Committee for risk assessment RAC. Opinion proposing harmonised classification and labelling at EU level of 2\u2010methylisothiazol\u20103(2H)\u2010one (ISO) Adopted 10 March2016. Available at:http:\/\/echa.europa.eu\/documents\/10162\/b32e77aa\u2010b720\u20104f66\u2010ad16\u2010a413dadf1631(last accessed 11 October 2016)."},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12387"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12598"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02169.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1996.tb02155.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12347"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01168.x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12184"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12524"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14825"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12733","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12733","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T03:38:55Z","timestamp":1695785935000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,28]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/cod.12733"],"URL":"https:\/\/doi.org\/10.1111\/cod.12733","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,28]]}}}