{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:37:05Z","timestamp":1791949025859,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T00:00:00Z","timestamp":1487030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Australian cushion bush (<jats:italic>Leucophyta brownii<\/jats:italic>) of the Compositae family of plants has become a popular pot and container plant. The plant produces the sesquiterpene lactone allergen calocephalin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the sensitizing potential of sesquiterpene lactones from cushion bush.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Materials\/Methods<\/jats:title><jats:p>Eleven Compositae\u2010sensitive patients were patch tested with seven sesquiterpene lactones isolated from cushion bush.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six of seven sesquiterpene lactones elicited positive reactions in 4 of 11 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The well\u2010known sesquiterpene lactone pseudoivalin and its derivative pseudoivalin acetate, as well as calocephalin and tomentosin, were confirmed to be sensitizers, whereas leucophytalin A and 4\u03b1\u2010hydroxy\u2010<jats:styled-content style=\"fixed-case\">5\u03b1H<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">10\u03b1H<\/jats:styled-content>\u20101,11(13)\u2010guaidien\u20108\u03b2,12\u2010olide were shown to be allergenic for the first time. The patch test reaction patterns seem to follow the chemical patterns, which may eventually make it possible to trace primary sensitizers and advise patients more precisely.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12757","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T08:53:16Z","timestamp":1487062396000},"page":"280-286","source":"Crossref","is-referenced-by-count":14,"title":["Allergenic sesquiterpene lactones from cushion bush (<i>Leucophyta brownii<\/i> Cass.): new and old sensitizers in a shrub\u2010turned\u2010a\u2010pot plant"],"prefix":"10.1111","volume":"76","author":[{"given":"Evy","family":"Paulsen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Centre, Odense University Hospital University of Southern Denmark  5000 Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette G.","family":"Hyldgaard","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Biotechnology and Environmental Technology University of Southern Denmark  5230 Odense M Denmark"},{"name":"Hygade ApS  5610 Assens Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus E.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre, Odense University Hospital University of Southern Denmark  5000 Odense C Denmark"},{"name":"Centre for Innovative Medical Technology Institute for Clinical Research and Odense University Hospital, University of Southern Denmark  5000 Odense C Denmark"},{"name":"Dermatological Investigations Scandinavia Institute of Clinical Research and Odense University Hospital, University of Southern Denmark  5000 Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flemming","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre, Odense University Hospital University of Southern Denmark  5000 Odense C Denmark"},{"name":"Dermatological Investigations Scandinavia Institute of Clinical Research and Odense University Hospital, University of Southern Denmark  5000 Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars P.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Biotechnology and Environmental Technology University of Southern Denmark  5230 Odense M Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12096"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1071\/CH9660143"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.0309cw.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b00208"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1973.tb119653.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1979.tb05536.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1997.tb01128.x"},{"key":"e_1_2_6_10_1","first-page":"210","volume-title":"Botanical Dermatology. 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