{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:22:48Z","timestamp":1772223768408,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T00:00:00Z","timestamp":1487030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with lower leg dermatitis, chronic venous insufficiency or chronic leg ulcers have a high prevalence of contact sensitization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify the current spectrum of contact allergens in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Data of the <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nformation <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>etwork of <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>epartments of <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ermatology on 5264 patients with the above diagnoses from the years 2003 to 2014 (study group) were compared with data on 4881 corresponding patients from 1994 to 2003 (historical control group) and with a current control group without these diagnoses (n\u2009=\u200955\u2009510).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Allergic contact dermatitis was diagnosed less frequently in the study group than in the historical control group (25.9% versus 16.9%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and contact sensitization to most allergens had declined. The allergen spectrum, however, was largely unchanged. Important allergens are <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>yroxylon pereirae<\/jats:italic> (balsam of <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>eru) (14.8% positive reactions), fragrance mix <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> (11.4%), lanolin alcohol (7.8%), colophonium (6.6%), neomycin sulfate (5.0%), cetearyl alcohol (4.4%), oil of turpentine (3.1%), and paraben mix (2.6%). Patch testing with additional series showed sensitization to <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>merchol <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\u2010101 (9.7%), <jats:italic>tert<\/jats:italic>\u2010butyl hydroquinone (8.7%), framycetin sulfate (5.0%), and gentamicin sulfate (3.1%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Topical preparations for treating the above\u2010mentioned conditions should not contain fragrances, <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>yroxylon pereirae<\/jats:italic>, and colophonium. The special allergen spectrum has to be considered in patch testing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12763","type":"journal-article","created":{"date-parts":[[2017,2,14]],"date-time":"2017-02-14T09:02:41Z","timestamp":1487062961000},"page":"151-158","source":"Crossref","is-referenced-by-count":53,"title":["The current spectrum of contact sensitization in patients with chronic leg ulcers or stasis dermatitis\u2009\u2013\u2009new data from the <scp>I<\/scp>nformation <scp>N<\/scp>etwork of <scp>D<\/scp>epartments of <scp>D<\/scp>ermatology (<scp>IVDK<\/scp>)"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3722-6383","authenticated-orcid":false,"given":"Cornelia","family":"Erfurt\u2010Berge","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Erlangen  91054 Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Geier","sequence":"additional","affiliation":[{"name":"Information Network of Departments of Dermatology (IVDK) University Medical Centre G\u00f6ttingen  37075 G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Mahler","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Erlangen  91054 Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-015-3668-z"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05917.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1998.tb00946.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-005-1053-z"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01541.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina47090072"},{"key":"e_1_2_7_8_1","first-page":"14","article-title":"Kontaktallergien bei Patienten mit Stauungsdermatitis oder Ekzem der Beine","volume":"44","author":"Lange\u2010Ionescu S","year":"1996","journal-title":"Derm Beruf Umwelt"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-010-1972-1"},{"key":"e_1_2_7_10_1","first-page":"131","article-title":"Leg ulcers. 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