{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:07:38Z","timestamp":1792591658112,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2017,5]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n The irritant sodium lauryl sulfate (\n SLS<\/jats:styled-content>\n ) is known to cause a decrease in the stratum corneum level of natural moisturizing factor (\n NMF<\/jats:styled-content>\n ), which in itself is associated with changes in corneocyte surface topography.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To explore this phenomenon in allergic contact dermatitis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patch testing was performed on patients with previously positive patch test reactions to potassium dichromate (\n C<\/jats:styled-content>\n r), nickel sulfate (\n N<\/jats:styled-content>\n i), methylchloroisothiazolinone (\n MCI<\/jats:styled-content>\n )\/methylisothiazolinone (\n MI<\/jats:styled-content>\n ), or\n p<\/jats:italic>\n \u2010phenylenediamine. Moreover, a control (pet.) patch and an irritant (\n SLS<\/jats:styled-content>\n ) patch were applied. After 3\u2009days, the stratum corneum from tested sites was collected, and\n NMF<\/jats:styled-content>\n levels and corneocyte morphology, expressed as the amount of circular nanosize objects, quantified according to the\n D<\/jats:styled-content>\n ermal\n T<\/jats:styled-content>\n exture\n I<\/jats:styled-content>\n ndex (\n DTI<\/jats:styled-content>\n ), were determined.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among allergens, only\n MCI<\/jats:styled-content>\n \/\n MI<\/jats:styled-content>\n reduced\n NMF<\/jats:styled-content>\n levels significantly, as did\n SLS<\/jats:styled-content>\n . Furthermore, only\n MCI<\/jats:styled-content>\n \/\n MI<\/jats:styled-content>\n caused remarkable changes at the microscopic level; the corneocytes were hexagonal\u2010shaped with pronounced cell borders and a smoother surface. The\n DTI<\/jats:styled-content>\n was increased after\n SLS<\/jats:styled-content>\n exposure but not after allergen exposure.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n MCI<\/jats:styled-content>\n \/\n MI<\/jats:styled-content>\n significantly decreased\n NMF<\/jats:styled-content>\n levels, similarly to\n SLS<\/jats:styled-content>\n . The altered corneocyte morphology suggests that skin barrier damage plays a role in the pathogenesis of\n MCI<\/jats:styled-content>\n \/\n MI<\/jats:styled-content>\n contact allergy. The\n DTI<\/jats:styled-content>\n seems to differentiate reactions to\n SLS<\/jats:styled-content>\n from those to the allergens tested, as\n SLS<\/jats:styled-content>\n was the only agent that caused a\n DTI<\/jats:styled-content>\n increase.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cod.12770","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T16:57:20Z","timestamp":1489510640000},"page":"287-295","source":"Crossref","is-referenced-by-count":41,"title":["Effect of allergens and irritants on levels of natural moisturizing factor and corneocyte morphology"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8833-531X","authenticated-orcid":false,"given":"Sjors A.","family":"Koppes","sequence":"first","affiliation":[{"name":"Academic Medical Center, Department: Coronel institute of Occupational Health Amsterdam Public Health Research Institute 1105 AZ Amsterdam The Netherlands"},{"name":"Department of Dermatology\u2010Allergology VU University Medical Centre 1081 HV Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana","family":"Ljubojevi\u0107 Had\u017eavdi\u0107","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology University Hospital Centre Zagreb and University of Zagreb School of Medicine 10000 Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivone","family":"Jakasa","sequence":"additional","affiliation":[{"name":"Faculty of Food Technology and Biotechnology, Laboratory for Analytical Chemistry, Department of Chemistry and Biochemistry University of Zagreb 10000 Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nika","family":"Franceschi","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, University Clinical Hospital Centre \u2018Sestre Milosrdnice\u2019 10000 Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Riethm\u00fcller","sequence":"additional","affiliation":[{"name":"Centre for Nanotechnology, Serend\u2010ip GmbH Centre for Nanotechnology 48149 M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru\u017eica","family":"Juraki\u0107 Ton\u010dic","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology University Hospital Centre Zagreb and University of Zagreb School of Medicine 10000 Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branka","family":"Marinovic","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology University Hospital Centre Zagreb and University of Zagreb School of Medicine 10000 Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhin","family":"Raj","sequence":"additional","affiliation":[{"name":"Skin Research Laboratory, Department of Pharmaceutics University College London WC1N 1AX London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony V.","family":"Rawlings","sequence":"additional","affiliation":[{"name":"Skin Research Laboratory, Department of Pharmaceutics University College London WC1N 1AX London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Voegeli","sequence":"additional","affiliation":[{"name":"DSM Nutritional Products Ltd. 4002 Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majella E.","family":"Lane","sequence":"additional","affiliation":[{"name":"Skin Research Laboratory, Department of Pharmaceutics University College London WC1N 1AX London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Haftek","sequence":"additional","affiliation":[{"name":"Laboratory of Tissue Biology and Therapeutic Engineering CNRS and University of Lyon UMR 5305 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique H.W.","family":"Frings\u2010Dresen","sequence":"additional","affiliation":[{"name":"Academic Medical Center, Department: Coronel institute of Occupational Health Amsterdam Public Health Research Institute 1105 AZ Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Rustemeyer","sequence":"additional","affiliation":[{"name":"Department of Dermatology\u2010Allergology VU University Medical Centre 1081 HV Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Kezic","sequence":"additional","affiliation":[{"name":"Academic Medical Center, Department: Coronel institute of Occupational Health Amsterdam Public Health Research Institute 1105 AZ Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5769(01)00171-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2002.00997.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2363"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08730.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12139"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12083"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02540.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.12.668"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.04.042"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.470105.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02652.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2012.08.003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.09.032"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.01.034"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701170"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2005.00106.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2008.00472.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12334"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2741\/4225"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/00032719.2013.789881"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12321"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2494.2007.00386.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2007.00214.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2011.00671.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12247"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.29"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12101"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1815"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807908200"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-27606-4_29"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12103.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01507.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.07.012"},{"key":"e_1_2_7_36_1","unstructured":"Agency USEP.Reregistration Eligibility Decision (RED) methylisothiazolinone 1998."},{"key":"e_1_2_7_37_1","unstructured":"Safety SCoC SCCS.Opinion on the mixture of 5\u2010chloro\u20102\u2010methylisothiazolin\u20103(2H)\u2010one and 2\u2010methylisothiazolin\u20103(2H)\u2010one 2009."},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00149-X"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12770","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T23:38:45Z","timestamp":1695771525000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,14]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/cod.12770"],"URL":"https:\/\/doi.org\/10.1111\/cod.12770","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,14]]}}}