{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:21:53Z","timestamp":1790396513882,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T00:00:00Z","timestamp":1492646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R108\u2010A10225"],"award-info":[{"award-number":["R108\u2010A10225"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008397","name":"Velux Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atopic dermatitis and hand eczema often impair the ability of people to work. Only a few studies have investigated whether individuals with loss\u2010of\u2010function filaggrin gene (<jats:italic><jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content><\/jats:italic>) mutations, who often have severe and early onset of dermatitis, experience occupational consequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the personal consequences of having atopic dermatitis and\/or hand eczema and <jats:italic>FLG<\/jats:italic> mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Adult <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>anes from the general population (n\u2009=\u20093247) and patients with atopic dermatitis and\/or hand eczema (n\u2009=\u2009496) were genotyped for common <jats:italic><jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content><\/jats:italic> mutations, and completed a questionnaire about skin symptoms and hand eczema. Socioeconomic variables, including disability pension, and information on work in risk occupations were retrieved from national registries. The reasons for granting disability pension were unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Disability pension was associated with hand eczema in the general population, especially among individuals with a history of atopic dermatitis. Moreover, self\u2010reported hand eczema and atopic dermatitis were associated with particularly high risk of disability pension among <jats:italic><jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content><\/jats:italic> mutation carriers [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 4.02 and 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 1.15\u201314.11; and <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 6.01 and 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2.37\u201315.34, respectively]. Furthermore, 60% of the <jats:italic><jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content><\/jats:italic> mutation carriers with atopic dermatitis who developed hand eczema had experienced symptoms before adulthood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the general population, self\u2010reported hand eczema and atopic dermatitis, particularly in individuals with a genetically impaired skin barrier, were associated with disability pension, suggesting that <jats:italic><jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content><\/jats:italic> mutations carriers with a history of atopic dermatitis and hand eczema could benefit from early attention with respect to choice of occupation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12786","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T09:15:50Z","timestamp":1492679750000},"page":"95-105","source":"Crossref","is-referenced-by-count":30,"title":["Hand eczema, atopic dermatitis and filaggrin mutations in adult <scp>D<\/scp>anes: a registry\u2010based study assessing risk of disability pension"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4253-6933","authenticated-orcid":false,"given":"Nina G.","family":"Heede","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy, The National Allergy Research Centre Copenhagen University Hospital Herlev\u2010Gentofte  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betina H.","family":"Thuesen","sequence":"additional","affiliation":[{"name":"Research Centre for Prevention and Health, the Capital Region of Denmark  2600 Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob P.","family":"Thyssen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, The National Allergy Research Centre Copenhagen University Hospital Herlev\u2010Gentofte  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Linneberg","sequence":"additional","affiliation":[{"name":"Research Centre for Prevention and Health, the Capital Region of Denmark  2600 Glostrup Denmark"},{"name":"Department of Clinical Experimental Research Rigshospitalet  2600 Glostrup Denmark"},{"name":"Faculty of Health and Medical Sciences, Department of Clinical Medicine University of Copenhagen  2200 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pal B.","family":"Szecsi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital Herlev\u2010Gentofte  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen","family":"Stender","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital Herlev\u2010Gentofte  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torkil","family":"Menn\u00e9","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, The National Allergy Research Centre Copenhagen University Hospital Herlev\u2010Gentofte  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, The National Allergy Research Centre Copenhagen University Hospital Herlev\u2010Gentofte  2900 Hellerup 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