{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:31:58Z","timestamp":1782973918364,"version":"3.54.5"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T00:00:00Z","timestamp":1495152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Toothpastes have widespread use in the population, and contain flavours to give a pleasant and often minty aroma. Flavours are prevalent allergens in toothpastes, and adverse reactions often present as perioral dermatitis or stomatitis. <jats:sc>l<\/jats:sc>\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>arvone, a mint flavour found in spearmint oil, is one of these allergens. There are few studies on contact allergy to <jats:sc>l<\/jats:sc>\u2010carvone, and some of them have indicated a positive relationship with oral lichenoid lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To qualitatively and quantitatively investigate the presence of <jats:sc>l<\/jats:sc>\u2010carvone in commercially available toothpastes on the <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>wedish market.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:sc>l<\/jats:sc>\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>arvone in 66 toothpastes was analysed with straight\u2010phase high\u2010performance liquid chromatography. The product labels were studied with regard to limonene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:sc>l<\/jats:sc>\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>arvone was found in 64 of 66 toothpastes (concentration: 0.00005\u20130.35%). In 10 of these, the concentration exceeded 0.1%. Higher concentrations of <jats:sc>l<\/jats:sc>\u2010carvone were found if limonene was  listed on the label.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The majority of toothpastes on the <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>wedish market contain <jats:sc>l<\/jats:sc>\u2010carvone, but the concentration hardly relates to the advertised flavour or labelled ingredients. It is hitherto unknown whether the found concentrations are sufficient for induction of contact allergy in individuals with healthy oral mucosa or in those with oral lichenoid lesions or other mucosal disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12803","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T11:01:18Z","timestamp":1495191678000},"page":"224-230","source":"Crossref","is-referenced-by-count":24,"title":["Quantification of <scp>l<\/scp>\u2010carvone in toothpastes available on the <scp>S<\/scp>wedish market"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3984-0210","authenticated-orcid":false,"given":"Liv","family":"Kroona","sequence":"first","affiliation":[{"name":"Department of Oral Pathology Faculty of Odontology Malm\u00f6 University  205 06 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Warfvinge","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Faculty of Odontology Malm\u00f6 University  205 06 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marl\u00e9ne","family":"Isaksson","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  205 02 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Ahlgren","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Faculty of Odontology Malm\u00f6 University  205 06 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Dahlin","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  205 02 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6sten","family":"S\u00f6rensen","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  205 02 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-3227","authenticated-orcid":false,"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  205 02 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350456"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1978.tb03788.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1995.tb00781.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2000.043004216.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215107000631"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2006.00300.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1995.tb00509.x"},{"key":"e_1_2_5_9_1","first-page":"42","article-title":"Toothpaste allergy diagnosis and management","volume":"3","author":"Zirwas M J","year":"2010","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02329.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01290.x"},{"key":"e_1_2_5_12_1","volume-title":"Comparative Study on Cosmetics Legislation in the EU and Other Principal Markets with Special Attention to so\u2010Called Borderline Products: Final Report. Study Prepared for European Commission, Directorate\u2010General Enterprise","author":"Risk and Policy Analysts Ltd","year":"2004"},{"key":"e_1_2_5_13_1","unstructured":"Council of the European Union European Parliament.Regulation (EC) No. 1223\/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products.OJ L 2009: 52: 59\u2013209."},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf1022077"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.4021"},{"key":"e_1_2_5_16_1","first-page":"1373","article-title":"Chemical diversity in Mentha spicata: antioxidant and potato sprout inhibition activity of its essential oils","volume":"6","author":"Chauhan S S","year":"2011","journal-title":"Nat Prod Commun"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2005.01.003"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527693153.ch3"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf047998s"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.1997.9700750"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2006.10.061"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ffj.1417"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules14010238"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1076\/phbi.41.6.421.17825"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1992.tb00129.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527693153.ch2"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12117"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.0459f.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05813.x"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.460615.x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05771.x"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2000.043006322.x"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01973.x"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2012.00908.x"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-013-0950-2"},{"key":"e_1_2_5_36_1","first-page":"31","article-title":"411: carvone contact allergy in southern Sweden\u2009\u2013\u2009a 15\u2010year retrospective study","volume":"70","author":"Kroona L","year":"2014","journal-title":"Contact Dermatitis"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12676"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-06241-4.00013-8"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1999.tb06009.x"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000112"},{"key":"e_1_2_5_41_1","unstructured":"European Commission.Commission Regulation (EU) 2015\/1221 of 24 July 2015 amending Regulation (EC) No. 1272\/2008 of the European Parliament and of the Council on classification labelling and packaging of substances and mixtures for the purposes of its adaptation to technical and scientific progress.OJ L 2015: 58: 10\u201323."},{"key":"e_1_2_5_42_1","unstructured":"SCCS (Scientific Committee on Consumer Safety) 1459\/11 opinion on fragrance allergens in cosmetic products 26\u201327 June 2012. Available at:http:\/\/ec.europa.eu\/health\/scientific_committees\/consumer_safety\/docs\/sccs_o_102.pdf(last accessed 01 March 2017)."},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2014.3806"},{"key":"e_1_2_5_44_1","unstructured":"International Fragrance Association.IFRA standards booklet. l\u2010Carvone: 6485\u201040\u20101 July 16 2008. Updated October 2009. Available at:www.ifraorg.org(last accessed August 12 2016)."},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/2190-4715-24-37"},{"key":"e_1_2_5_46_1","unstructured":"European Union.Regulation (EC) no. 1907\/2006 of the European parliament and of the Council of 18 December 2006 concerning the registration evaluation authorisation and restriction of chemicals (REACH) establishing a European chemicals agency amending Directive 1999\/45\/EC and repealing Council Regulation (EEC) no. 793\/93 and Commission Regulation (EC) no. 1488\/94 as well as Council Directive 76\/769\/EEC and Commission Directives 91\/155\/EEC 93\/67\/EEC 93\/105\/EC and 2000\/21\/EC (text with EEA relevance) 2006. Available at:http:\/\/data.europa.eu\/eli\/reg\/2006\/1907\/2016\u201006\u201021(retrieved August 2016)."},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2007.10.008"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2008.05.011"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2014.11.014"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08162.x"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1159\/isbn.978-3-318-02207-0"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1991.01680060090010"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14241"},{"key":"e_1_2_5_54_1","first-page":"1","article-title":"A prevalence study of oral mucosal lesions in an adult Swedish population","volume":"36","author":"Axell T","year":"1976","journal-title":"Odontol Revy Suppl"},{"key":"e_1_2_5_55_1","first-page":"60","article-title":"P075: Gallates, as well as hydroperoxides of limonene and linalool, are more frequent and relevant sensitizers than any cosmetic ingredient included in the European Baseline Series","volume":"75","author":"Spiewak R","year":"2016","journal-title":"Contact Dermatitis"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1993.tb03511.x"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2012.07933_suppl.x"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12803","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12803","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:03:50Z","timestamp":1696395830000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,19]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/cod.12803"],"URL":"https:\/\/doi.org\/10.1111\/cod.12803","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,19]]}}}