{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:34:28Z","timestamp":1790879668841,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T00:00:00Z","timestamp":1494892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>For cosmetics, it is mandatory to label 26 fragrance substances, including all constituents of fragrance mix <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">FM I<\/jats:styled-content>) and fragrance mix <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">FM II<\/jats:styled-content>). Earlier reports have not included oxidized <jats:styled-content style=\"fixed-case\"><jats:italic>R<\/jats:italic><\/jats:styled-content>\u2010limonene [hydroperoxides of <jats:styled-content style=\"fixed-case\"><jats:italic>R<\/jats:italic><\/jats:styled-content>\u2010limonene (<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>im\u2010<jats:styled-content style=\"fixed-case\">OOH<\/jats:styled-content>)] and oxidized linalool [hydroperoxides of linalool (<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>in\u2010<jats:styled-content style=\"fixed-case\">OOH<\/jats:styled-content>)], and breakdown testing of <jats:styled-content style=\"fixed-case\">FM I<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FM II<\/jats:styled-content> has mainly been performed in selected, mix\u2010positive patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To report the prevalence of sensitization to the 26 fragrances, and to assess concomitant reactivity to <jats:styled-content style=\"fixed-case\">FM I<\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">FM II<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study on consecutive dermatitis patients patch tested with the 26 fragrances and the <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropean baseline series from 2010 to 2015 at a single university clinic was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 6004 patients, 940 (15.7%, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 14.7\u201316.6%) were fragrance\u2010sensitized. Regarding the single fragrances, most patients were sensitized to <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>in\u2010<jats:styled-content style=\"fixed-case\">OOH<\/jats:styled-content> (3.9%), <jats:italic><jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>vernia furfuracea<\/jats:italic> (3.0%), <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>im\u2010<jats:styled-content style=\"fixed-case\">OOH<\/jats:styled-content> (2.5%), and hydroxyisohexyl 3\u2010cyclohexene carboxaldehyde (2.1%). Significantly fewer patients were \u2018<jats:styled-content style=\"fixed-case\">FM I<\/jats:styled-content>\u2010positive and constituent\u2010positive\u2019 than \u2018<jats:styled-content style=\"fixed-case\">FM II<\/jats:styled-content>\u2010positive and constituent\u2010positive\u2019 (32.7% versus 57.0%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Additionally, significantly more patients were \u2018<jats:styled-content style=\"fixed-case\">FM II<\/jats:styled-content>\u2010negative but constituent\u2010positive\u2019 than \u2018<jats:styled-content style=\"fixed-case\">FM I<\/jats:styled-content>\u2010negative but constituent\u2010positive\u2019 (12.4% versus 3.2%, <jats:italic>p<\/jats:italic>\u2009=\u20090.0008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Non\u2010mix fragrances are the most important single fragrance allergens among consecutive patients. The test concentration of the single <jats:styled-content style=\"fixed-case\">FM I<\/jats:styled-content> constituents should be increased when possible.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12822","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T23:42:43Z","timestamp":1494978163000},"page":"270-279","source":"Crossref","is-referenced-by-count":64,"title":["Non\u2010mix fragrances are top sensitizers in consecutive dermatitis patients\u2009\u2013\u2009a cross\u2010sectional study of the 26 <scp>EU<\/scp>\u2010labelled fragrance allergens"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8718-6140","authenticated-orcid":false,"given":"Niels H.","family":"Bennike","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy, National Allergy Research Centre, Herlev\u2010Gentofte Hospital University of Copenhagen  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Zachariae","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Herlev\u2010Gentofte Hospital University of Copenhagen  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, National Allergy Research Centre, Herlev\u2010Gentofte Hospital University of Copenhagen  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12420"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14167"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12492"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12128"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15180"},{"key":"e_1_2_6_7_1","first-page":"26","article-title":"Directive 2003\/15\/EC of the EP and of the Council of 27 February 2003 amending Council directive 76\/768\/EEC","volume":"66","year":"2003","journal-title":"Off J Eur Union"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12536"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00565.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00563.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1995.tb00834.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1999.tb06129.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e31824a6104"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12056"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ffj.3247"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07170.x"},{"key":"e_1_2_6_18_1","unstructured":"SCCS\/1459\/11 Opinion on fragrance allergens in cosmetic products 2012. 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