{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:22:04Z","timestamp":1772223724852,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T00:00:00Z","timestamp":1499385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fragrance mix <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content> I) and fragrance mix <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">FM II<\/jats:styled-content>) are included in the <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropean baseline series as screening substances for fragrance contact allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the frequency of allergic reactions to <jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content> I, <jats:styled-content style=\"fixed-case\">FM II<\/jats:styled-content> and their ingredients in consecutively patch tested patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A retrospective analysis of data from 4430 patients patch tested between 2009 and 2015 was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the patients, 6.5% were <jats:styled-content style=\"fixed-case\">FM I<\/jats:styled-content>\u2010positive and 3.2% were <jats:styled-content style=\"fixed-case\">FM II<\/jats:styled-content>\u2010positive. Forty\u2010five per cent of <jats:styled-content style=\"fixed-case\">FM I<\/jats:styled-content>\u2010positive patients did not have positive reactions to <jats:styled-content style=\"fixed-case\">FM I<\/jats:styled-content> ingredients. Thirty\u2010five per cent of those who were <jats:styled-content style=\"fixed-case\">FM II<\/jats:styled-content>\u2010positive did not have positive reactions to <jats:styled-content style=\"fixed-case\">FM II<\/jats:styled-content> ingredients. Twenty\u2010seven per cent of those with positive reactions to one or more of the <jats:styled-content style=\"fixed-case\">FM I<\/jats:styled-content> ingredients were <jats:styled-content style=\"fixed-case\">FM I<\/jats:styled-content>\u2010negative, and 36% of those who had positive reactions to one or more of the <jats:styled-content style=\"fixed-case\">FM II<\/jats:styled-content> ingredients were <jats:styled-content style=\"fixed-case\">FM II<\/jats:styled-content>\u2010negative. The allergens with the highest pick\u2010up rates were <jats:italic><jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>vernia prunastri<\/jats:italic> (1.8%), cinnamal (1.3%), citral (1.2%), and hydroxyisohexyl 3\u2010cyclohexene carboxaldehyde (1.2%). Significant differences were observed in the proportions of positive reactions to <jats:styled-content style=\"fixed-case\">FM I<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">FM II<\/jats:styled-content>, eugenol, isoeugenol, and farnesol when results from patch testing with materials from different suppliers were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is a risk of missing fragrance contact allergy when testing with only the fragrance mixes is performed. The use of preparations from different suppliers may affect the patch test results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12834","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T12:23:17Z","timestamp":1499430197000},"page":"280-287","source":"Crossref","is-referenced-by-count":32,"title":["Simultaneous patch testing with fragrance mix <scp>I<\/scp>, fragrance mix <scp>II<\/scp> and their ingredients in southern <scp>S<\/scp>weden between 2009 and 2015"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6172-9274","authenticated-orcid":false,"given":"Martin","family":"Mowitz","sequence":"first","affiliation":[{"name":"Lund University, Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  205 02 Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Svedman","sequence":"additional","affiliation":[{"name":"Lund University, Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  205 02 Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Zimerson","sequence":"additional","affiliation":[{"name":"Lund University, Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  205 02 Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marl\u00e9ne","family":"Isaksson","sequence":"additional","affiliation":[{"name":"Lund University, Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  205 02 Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Pont\u00e9n","sequence":"additional","affiliation":[{"name":"Lund University, Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  205 02 Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-3227","authenticated-orcid":false,"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[{"name":"Lund University, Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  205 02 Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14151"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14297"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12056"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12171"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12522"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01098.x"},{"key":"e_1_2_5_8_1","volume-title":"Manual of Contact Dermatitis","author":"Fregert S","year":"1981"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11143.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12300"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01759.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07170.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12468"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1995.tb00834.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ffj.3247"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12598"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx700017v"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12009"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12234"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12507"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ffj.1916"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-003-0426-3"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12126"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1725"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12312"},{"key":"e_1_2_5_26_1","unstructured":"BruzeM MowitzM OfenlochRet\u2009al.The significance of batch and patch test method in the establishing of contact allergy to fragrance mix I. 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