{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:46:21Z","timestamp":1790520381235,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T00:00:00Z","timestamp":1499731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008245","name":"Edvard Welanders Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Contact allergy to aluminium has been reported more frequently in recent years. It has been pointed out that positive patch test reactions to aluminium may not be reproducible on retesting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate possible variations in patch test reactivity to aluminium over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010one adults, who had previously reacted positively to aluminium, were patch tested with equimolar dilution series in pet. of aluminium chloride hexahydrate and aluminium lactate, four times over a period of 8\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010six of 84 (43%) serial dilution tests with aluminium chloride hexahydrate and 49 of 84 (58%) serial dilution tests with aluminium lactate gave negative results. The range of reactivity varied between a negative reaction to aluminium chloride hexahydrate at 10% and\/or to aluminium lactate at 12%, and a positive reaction to aluminium chloride hexahydrate at 0.1% and\/or to aluminium lactate at 0.12%. The highest individual difference in test reactivity noticed was 320\u2010fold when the two most divergent minimal eliciting concentrations were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The patch test reactivity to aluminium varies over time. Aluminium\u2010allergic individuals may have false\u2010negative reactions. Therefore, retesting with aluminium should be considered when there is a strong suspicion of aluminium contact allergy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12836","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T08:06:39Z","timestamp":1499760399000},"page":"288-296","source":"Crossref","is-referenced-by-count":29,"title":["Variation in aluminium patch test reactivity over time"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3530-4234","authenticated-orcid":false,"given":"Ingrid","family":"Siemund","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University  205 02 Malm\u00f6 Sweden"},{"name":"Department of Dermatology and Venereology Sk\u00e5ne University Hospital, Lund University  221 85 Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6172-9274","authenticated-orcid":false,"given":"Martin","family":"Mowitz","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University  205 02 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Zimerson","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University  205 02 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-3227","authenticated-orcid":false,"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University  205 02 Malm\u00f6 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