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In this article, we provide a general introduction to immune responses to contact allergens, and discuss the literature concerning immune responses to mixtures of allergens. According to the existing evidence, increased responses are induced following sensitization with combinations of allergens as compared with single allergens. The response to a mixture of allergens can be both additive and synergistic, depending on the dose and combination of allergens. Importantly, sensitization with combinations of either fragrance allergens or metal salts can result in increased challenge responses to specific allergens within the mixture. Taken together, the immune responses to mixtures of allergens are complex, and further studies are required to obtain the necessary knowledge to improve consumer safety.<\/jats:p>","DOI":"10.1111\/cod.12847","type":"journal-article","created":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T07:52:37Z","timestamp":1499241157000},"page":"133-142","source":"Crossref","is-referenced-by-count":43,"title":["Immunological, chemical and clinical aspects of exposure to mixtures of contact allergens"],"prefix":"10.1111","volume":"77","author":[{"given":"Charlotte M.","family":"Bonefeld","sequence":"first","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Immunology and Microbiology University of Copenhagen 2200 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Geisler","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, Department of Immunology and Microbiology University of 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