{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:02:13Z","timestamp":1790805733627,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,8,6]],"date-time":"2017-08-06T00:00:00Z","timestamp":1501977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Antiretroviral drug hypersensitivity in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> patients is common. Publications have shown that <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>bacavir (<jats:styled-content style=\"fixed-case\">ABC<\/jats:styled-content>) patch testing is useful in confirming <jats:styled-content style=\"fixed-case\">ABC<\/jats:styled-content> hypersensitivity in 24\u201350% of cases with a 100% sensitivity of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>*5701 in patch test positive cases. However, <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>evirapine (<jats:styled-content style=\"fixed-case\">NVP<\/jats:styled-content>) patch testing has not been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>(1) To evaluate the usefulness and safety of <jats:styled-content style=\"fixed-case\">NVP<\/jats:styled-content> patch testing in <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>hai <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">NVP<\/jats:styled-content> hypersensitivity. (2) To assess the correlation of positive patch tests with <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>*3505.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Patients were classified into two groups: (1) study group of 20 <jats:styled-content style=\"fixed-case\">HIV NVP<\/jats:styled-content> hypersensitivity patients and (2) control group of 15 volunteers without <jats:styled-content style=\"fixed-case\">NVP<\/jats:styled-content> hypersensitivity. Both groups were patch tested with purified and commercialized form of <jats:styled-content style=\"fixed-case\">NVP<\/jats:styled-content> in various vehicles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">NVP<\/jats:styled-content> hypersensitivity were patch test positive. All controls tested negative. Three <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> patients were positive for <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>*3505 and the two patients with positive patch testing were both <jats:styled-content style=\"fixed-case\">HLA\u2010B<\/jats:styled-content>*3505 positive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">NVP<\/jats:styled-content> patch testing in <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>hai <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> patients is safe and can be used to help confirm the association between <jats:styled-content style=\"fixed-case\">NVP<\/jats:styled-content> and hypersensitivity skin reactions. <jats:styled-content style=\"fixed-case\">NVP<\/jats:styled-content> patch test results significantly correlated with <jats:styled-content style=\"fixed-case\">HLA\u2010B<\/jats:styled-content>*3505. The sensitivity of <jats:styled-content style=\"fixed-case\">HLA\u2010B<\/jats:styled-content>*3505 for positive patch test was 100%.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12849","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T04:56:37Z","timestamp":1502081797000},"page":"379-384","source":"Crossref","is-referenced-by-count":7,"title":["Nevirapine patch testing in <scp>T<\/scp>hai human immunodeficiency virus  infected  patients with nevirapine drug hypersensitivity"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2794-9086","authenticated-orcid":false,"given":"Piyatida","family":"Prasertvit","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Division of Dermatology, Department of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand 10400"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angkana","family":"Chareonyingwattana","sequence":"additional","affiliation":[{"name":"Center for Medical Genomics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penpun","family":"Wattanakrai","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Dermatology, Department of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand 10400"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.02.059"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06429.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282f7cb60"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2012.01409.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706135"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/529382"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32831d0faf"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-03827-3_26"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2004.12.024"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.450601.x"},{"key":"e_1_2_6_12_1","first-page":"15","article-title":"Testing for drug hypersensitivity syndromes","volume":"34","author":"Rive C M","year":"2013","journal-title":"Clin Biochem Rev"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.04.013"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1461-5347(00)00295-9"},{"key":"e_1_2_6_15_1","first-page":"218","article-title":"In\u2009vivo evaluation of self emulsifying drug delivery system for oral delivery of nevirapine","volume":"76","author":"Chudasama A S","year":"2014","journal-title":"Indian J Pharm Sci"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx400098z"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200211080-00017"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12849","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T11:59:51Z","timestamp":1696679991000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,6]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/cod.12849"],"URL":"https:\/\/doi.org\/10.1111\/cod.12849","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,6]]}}}