{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:58:44Z","timestamp":1774270724539,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T00:00:00Z","timestamp":1501200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Recent animal tests have indicated cross\u2010reactivity between methylisothiazolinone (MI<\/jats:styled-content>), octylisothiazolinone (OIT<\/jats:styled-content>), and benzisothiazolinone (BIT<\/jats:styled-content>).<\/jats:p><\/jats:sec>Objectives<\/jats:title>To retrospectively analyse concomitant reactions to different isothiazolinones in patients in an occupational dermatology clinic during the ongoing MI<\/jats:styled-content> contact allergy epidemic.<\/jats:p><\/jats:sec>Methods<\/jats:title>We searched patch test files (J<\/jats:styled-content>anuary 2012 to F<\/jats:styled-content>ebruary 2017) for patients with allergic reactions to OIT<\/jats:styled-content>, BIT,<\/jats:styled-content> and MI<\/jats:styled-content>, and analysed their patch test results, occupations, exposure, and diagnoses.<\/jats:p><\/jats:sec>Results<\/jats:title>We found 61 (9.4%) allergic reactions to MI<\/jats:styled-content>, 19 (2.9%) reactions to OIT<\/jats:styled-content> and 9 (1.4%) reactions to BIT<\/jats:styled-content> in a total of 647 consecutively tested patients. Seventeen (89%) of the OIT<\/jats:styled-content>\u2010positive patients had concomitant reactions to MI<\/jats:styled-content>, whereas only 3 (33%) BIT<\/jats:styled-content>\u2010positive patients had allergic reactions to MI<\/jats:styled-content>. The MI<\/jats:styled-content> reactions in OIT<\/jats:styled-content>\u2010positive patients were almost exclusively extreme reactions (+++). Exposure to OIT<\/jats:styled-content> was identified in 26% of the OIT<\/jats:styled-content>\u2010positive patients, and 56% of the BIT<\/jats:styled-content>\u2010positive patients had been exposed to BIT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Allergic reactions to OIT<\/jats:styled-content> were strongly associated with extreme reactions to MI<\/jats:styled-content>, which suggests cross\u2010sensitization. In contrast, BIT<\/jats:styled-content> reactions were mostly independent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12855","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T09:36:58Z","timestamp":1501234618000},"page":"385-389","source":"Crossref","is-referenced-by-count":27,"title":["Patterns of concomitant allergic reactions in patients suggest cross\u2010sensitization between octylisothiazolinone and methylisothiazolinone"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5595-5512","authenticated-orcid":false,"given":"Kristiina","family":"Aalto\u2010Korte","sequence":"first","affiliation":[{"name":"Occupational Medicine Finnish Institute of Occupational Health (FIOH) 00250 Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katri","family":"Suuronen","sequence":"additional","affiliation":[{"name":"Occupational Medicine Finnish Institute of Occupational Health (FIOH) 00250 Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14825"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12249"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12347"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12741"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12186"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01033.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.10.1326"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12670"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12855","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12855","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T11:59:45Z","timestamp":1696679985000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,28]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/cod.12855"],"URL":"https:\/\/doi.org\/10.1111\/cod.12855","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,28]]}}}