{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:20:58Z","timestamp":1772223658058,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T00:00:00Z","timestamp":1501804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"AFA insurance finances"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>During rubber vulcanization, new compounds can be formed.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To report a case of allergic shoe dermatitis in which the search for the allergen ultimately led to the identification of dimethylthiocarbamylbenzothiazole sulfide (DMTBS)<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>A female presented with eczema on her feet after wearing S<\/jats:styled-content>perry T<\/jats:styled-content>op S<\/jats:styled-content>ider\u00ae canvas sneakers. Patch testing was performed with the E<\/jats:styled-content>uropean baseline series, additional series, shoe materials, and extracts of shoe materials. Thin\u2010layer chromatography (TLC<\/jats:styled-content>) was performed for additional patch testing, and high\u2010performance liquid chromatography and gas chromatography\u2013mass spectometry were used for chemical analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>Positive reactions were found to thiuram mix (+), tetramethylthiuram monosulfide (TMTM<\/jats:styled-content>) (+), shoe material (+), and shoe extracts in eth. (++) and acetone (+). The extracts did not contain TMTM<\/jats:styled-content> or other components of thiuram mix. TLC<\/jats:styled-content> strips yielded a positive reaction (+) to one spot, whereas chemical analysis gave a negative result. Thereafter, a similar sneaker from another patient with shoe dermatitis was analysed, and DMBTS<\/jats:styled-content> was identified. New extracts of the shoe of our first patient were then also shown to contain DMTBS<\/jats:styled-content>. DMTBS<\/jats:styled-content> as culprit allergen was confirmed by positive patch testing with a dilution series with DMTBS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>DMBTS<\/jats:styled-content> was identified as the culprit allergen in shoe dermatitis, giving rise to compound allergy. The positive reaction to TMTM<\/jats:styled-content> was considered to represent cross\u2010reactivity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12857","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T11:21:12Z","timestamp":1501845672000},"page":"7-11","source":"Crossref","is-referenced-by-count":16,"title":["Allergic contact dermatitis caused by dimethylthiocarbamylbenzothiazole sulfide (DMTBS<\/scp>) in canvas shoes: in search of the culprit allergen"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0766-4382","authenticated-orcid":false,"given":"Marie L.","family":"Schuttelaar","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Groningen, University Medical Centre Groningen 9700 RB Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joost M.","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Groningen, University Medical Centre Groningen 9700 RB Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malin","family":"Engfeldt","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital 205 02 Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilde","family":"Lapeere","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ghent University Hospital 9000 Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9805-3439","authenticated-orcid":false,"given":"An","family":"Goossens","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital KU Leuven 3000 Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-3227","authenticated-orcid":false,"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital 205 02 Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Persson","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital 205 02 Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola","family":"Bergendorff","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital 205 02 Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12168"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-45395-3_12"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2003.00009.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/cod.12342","article-title":"Thin\u2010layer chromatography and gas chromatography\u2013mass spectrometry examination of shoe materials from patients with shoe dermatitis","volume":"72","author":"Febriana A","year":"2015","journal-title":"Contact Dermatitis"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","DOI":"10.1111\/cod.12886","article-title":"Contact dermatitis caused by a new rubber compound detected in canvas 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