{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:17Z","timestamp":1787014037877,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T00:00:00Z","timestamp":1505174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG WE 1919\/5\u20101"],"award-info":[{"award-number":["DFG WE 1919\/5\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Hand eczema, which is frequently caused by delayed\u2010type allergy, is treated with 9\u2010\n cis<\/jats:italic>\n \u2010retinoic acid (9cis\n RA<\/jats:styled-content>\n ). However, knowledge on how 9cis\n RA<\/jats:styled-content>\n modulates skin immunity is sparse.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n As dendritic cells (\n DCs<\/jats:styled-content>\n ) are central in the pathogenesis of contact allergy, we investigated 9cis\n RA<\/jats:styled-content>\n modulation of\n DC<\/jats:styled-content>\n function in murine contact hypersensitivity (\n CHS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n 9cis\n RA<\/jats:styled-content>\n \u2010differentiated\n DCs<\/jats:styled-content>\n (9cis\n RA<\/jats:styled-content>\n \u2010\n DCs<\/jats:styled-content>\n ) were analysed for phenotype and function.\n In\u2009vivo<\/jats:italic>\n 9cis\n RA<\/jats:styled-content>\n \u2010\n DCs<\/jats:styled-content>\n were tested in the\n CHS<\/jats:styled-content>\n model.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n 9cis\n RA<\/jats:styled-content>\n induces the differentiation of a distinct\n CD<\/jats:styled-content>\n 103\n \u2212<\/jats:sup>\n \u2009\n CD<\/jats:styled-content>\n 207\n \u2212<\/jats:sup>\n regulatory\n DC<\/jats:styled-content>\n phenotype.\n CD<\/jats:styled-content>\n 11c\n +<\/jats:sup>\n DCs<\/jats:styled-content>\n differentiated with 9cis\n RA<\/jats:styled-content>\n have lower expression of major histocompatibility complex\u2010\n II<\/jats:styled-content>\n and costimulatory molecules, but conversely have higher expression of the inhibitory coreceptor\n PD<\/jats:styled-content>\n 1\u2010\n L<\/jats:styled-content>\n . 9cis\n RA<\/jats:styled-content>\n \u2010\n DC<\/jats:styled-content>\n culture does not induce the expression of proinflammatory cytokines, but strongly enhances osteopontin (\n OPN<\/jats:styled-content>\n ) secretion. 9cis\n RA<\/jats:styled-content>\n \u2010\n DCs<\/jats:styled-content>\n are compromised in the induction of\n T<\/jats:styled-content>\n cell proliferation\n in\u2009vitro<\/jats:italic>\n , but efficiently convert naive\n T<\/jats:styled-content>\n cells into regulatory\n T<\/jats:styled-content>\n cells (\n T<\/jats:styled-content>\n regs). Notably,\n OPN<\/jats:styled-content>\n \u2010deficient 9cis\n RA<\/jats:styled-content>\n \u2010\n DCs<\/jats:styled-content>\n show a loss of\n T<\/jats:styled-content>\n reg\u2010inducing function, which is re\u2010established by substituting\n OPN<\/jats:styled-content>\n .\n In\u2009vivo<\/jats:italic>\n , in allergic mice, allergen\u2010primed 9cis\n RA<\/jats:styled-content>\n \u2010\n DCs<\/jats:styled-content>\n suppress allergic inflammation and induce\n T<\/jats:styled-content>\n reg accumulation in skin draining lymph nodes.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This study describes 9cis\n RA<\/jats:styled-content>\n \u2010mediated differentiation of a distinct\n DC<\/jats:styled-content>\n phenotype that relies on\n OPN<\/jats:styled-content>\n for\n T<\/jats:styled-content>\n reg transformation and suppresses established\n CHS<\/jats:styled-content>\n through\n T<\/jats:styled-content>\n reg induction.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cod.12868","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T04:22:44Z","timestamp":1505190164000},"page":"41-54","source":"Crossref","is-referenced-by-count":15,"title":["9\u2010\n cis<\/i>\n \u2010\n R<\/scp>\n etinoic acid induces a distinct regulatory dendritic cell phenotype that modulates murine delayed\u2010type allergy"],"prefix":"10.1111","volume":"78","author":[{"given":"Lea\u2010Franziska","family":"Kraus","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy University of Ulm 89081 Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Scheurmann","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University of Ulm 89081 Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis F.","family":"Frenzel","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University of Ulm 89081 Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpaslan","family":"Tasdogan","sequence":"additional","affiliation":[{"name":"Institute for Immunology University of Ulm 89081 Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4071-8792","authenticated-orcid":false,"given":"Johannes M.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University of Ulm 89081 Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08487.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2378"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2011.09.012"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070602"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.284"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00569"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02148.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030390"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40926"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141623"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nri2460","article-title":"Regulation 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