{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T08:09:06Z","timestamp":1770451746704,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T00:00:00Z","timestamp":1508198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002706","name":"AFA insurance","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002706","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In 2015 and 2016, female patients in Flanders consulted a dermatologist because they developed skin lesions after wearing a specific brand of canvas shoes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify the culprit allergen in the shoes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighteen young females aged 14\u201322\u2009years presented with itching and erythematous to purple\u2010coloured eczematous lesions on both feet. They were patch tested by 10 dermatologists with the European baseline series. Some patients underwent testing with additional series. Pieces of the shoe fabrics were tested in 11 of 18 patients. Chemical analysis of the shoe materials was performed. Finally, patients were tested with a thin\u2010layer chromatogram of the shoe extracts and dilutions of the suspected rubber compound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 18 patients showed positive reactions to thiuram mix. Ten of 11 patients reacted to a piece of shoe fabric. Chemical analysis showed the presence of dimethylthiocarbamylbenzothiazole sulfide (DMTBS). No thiurams were detected. Four patients tested with the chromatogram developed positive reactions to DMTBS. Positive reactions to low concentrations were observed in the 4 patients tested with a DMTBS dilution series; one patient reacted to 0.00001% in acetone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DMTBS, the culprit allergen, is a component formed during rubber vulcanization that probably cross\u2010reacts with the thiuram mix.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12886","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T06:38:43Z","timestamp":1508222323000},"page":"12-17","source":"Crossref","is-referenced-by-count":34,"title":["Contact dermatitis caused by a new rubber compound detected in canvas shoes"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4610-4599","authenticated-orcid":false,"given":"Eva","family":"Hulstaert","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Gent  9000, Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola","family":"Bergendorff","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  205 02, Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Persson","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  205 02, Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9805-3439","authenticated-orcid":false,"given":"An","family":"Goossens","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital KU Leuven  3000, Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liesbeth","family":"Gilissen","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital KU Leuven  3000, Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malin","family":"Engfeldt","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  205 02, Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-3227","authenticated-orcid":false,"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  205 02, Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0766-4382","authenticated-orcid":false,"given":"Marie L.","family":"Schuttelaar","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Groningen, University Medical Centre Groningen  9700 RB, Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joost M.","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Groningen, University Medical Centre Groningen  9700 RB, Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilde","family":"Lapeere","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Gent  9000, Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02046.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/978-3-642-03827-3_41","volume-title":"Contact Dermatitis","author":"Goossens A","year":"2011"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12951"},{"key":"e_1_2_7_5_1","first-page":"56","article-title":"Allergic contact dermatitis from canvas shoes. Oral presentation at European Society of Contact Dermatitis in Manchester","volume":"75","author":"Goossens A","year":"2016","journal-title":"Contact Dermatitis"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01194.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.00912.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2003.00009.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-45395-3_12"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12670"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01078.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2003.0270.x"},{"key":"e_1_2_7_14_1","first-page":"248","article-title":"Vesicular palmar eczema from the neoprene tongue of an ankle support","volume":"42","author":"Haapasaari K M","year":"2000","journal-title":"Contact Dermatitis"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12018"},{"key":"e_1_2_7_16_1","first-page":"39","article-title":"Dimethyldithiocarbamylbenzothiazole sulfide: an unexpectedly strong rubber contact allergen","volume":"75","author":"Pont\u00e9n A","year":"2016","journal-title":"Contact Dermatitis"},{"key":"e_1_2_7_17_1","article-title":"Allergic contact dermatitis from dimethylthiocarbamylbenzothiazole sulfide (DMTBS) in canvas shoes: in search of the culprit allergen","author":"Schuttelaar M L","year":"2017","journal-title":"Contact Dermatitis"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12168"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12886","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12886","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T23:46:44Z","timestamp":1696031204000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,17]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/cod.12886"],"URL":"https:\/\/doi.org\/10.1111\/cod.12886","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,17]]}}}