{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:32:15Z","timestamp":1791855135579,"version":"4.3.4"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81301360 and 81573075"],"award-info":[{"award-number":["81301360 and 81573075"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573075 and 81301360"],"award-info":[{"award-number":["81573075 and 81301360"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sensitive skin is defined as a spectrum of unpleasant sensations in response to a variety of stimuli. However, only some skin care products provoke cutaneous symptoms in individuals with sensitive skin. Hence, it would be useful to identify products that could provoke cutaneous symptoms in individuals with sensitive skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess whether vehicles, as well as certain branded skin care products, can alter epidermal function following topical applications to normal mouse skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Following topical applications of individual vehicle or skin care product to <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>\/6<jats:styled-content style=\"fixed-case\">J<\/jats:styled-content> mice twice daily for 4\u2009days, transepidermal water loss (<jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content>) rates, stratum corneum (<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>) hydration and skin surface p<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content> were measured on treated versus untreated mouse skin with an <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content>A5 device and p<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\u2009900 p<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content> meter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results show that all tested products induced abnormalities in epidermal functions of varying severity, including elevations in <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content> and skin surface p<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>, and reduced <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content> hydration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that mice can serve as a predictive model that could be used to evaluate the potential safety of skin care products in humans with sensitive skin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12909","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T08:40:43Z","timestamp":1511167243000},"page":"151-158","source":"Crossref","is-referenced-by-count":32,"title":["Skin care products can aggravate epidermal function: studies in a murine model suggest a pathogenic role in sensitive skin"],"prefix":"10.1111","volume":"78","author":[{"given":"Zhengxiao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an 710004 China"},{"name":"Dermatology Service, Veterans Affairs Medical Center, and Department of Dermatology University of California  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhi","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Disease (Ministry of State 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