{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:23:32Z","timestamp":1777533812011,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T00:00:00Z","timestamp":1510099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Calcipotriol, a synthetic vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> analogue, is widely used for the topical treatment of psoriasis. It often causes irritant reactions, whereas allergic contact dermatitis has less commonly been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To report on 6 patients (among them an 11\u2010year\u2010old child) who presented with eczematous lesions complicating pre\u2010existing dermatitis, observed in our tertiary referral patch test clinic between 2004 and 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patch tests were performed with the commercial preparation used by the patients and\/or its ingredients, including calcipotriol (2 or 10\u2009\u00b5g\/ml in isopropyl alcohol), according to ESCD patch test guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Allergic contact dermatitis was confirmed in all cases, and the lesions improved following treatment with topical corticosteroids and\/or oral medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>When topical treatment with calcipotriol fails to improve, or even worsens, existing skin lesions, contact allergy should be suspected. A patch test concentration of 2\u2009\u00b5g\/ml in isopropyl alcohol seems to be the most suitable. According to the literature, patients sensitized to calcipotriol may tolerate topical therapy with other vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>3 analogues, particularly tacalcitol.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12910","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T08:53:18Z","timestamp":1510131198000},"page":"139-142","source":"Crossref","is-referenced-by-count":13,"title":["Allergic contact dermatitis caused by calcipotriol"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0927-3104","authenticated-orcid":false,"given":"Liesbeth","family":"Gilissen","sequence":"first","affiliation":[{"name":"Contact Allergy Unit, Department of Dermatology University Hospitals KU Leuven  3000 Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Huygens","sequence":"additional","affiliation":[{"name":"Contact Allergy Unit, Department of Dermatology University Hospitals KU Leuven  3000 Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9805-3439","authenticated-orcid":false,"given":"An","family":"Goossens","sequence":"additional","affiliation":[{"name":"Contact Allergy Unit, Department of Dermatology University Hospitals KU Leuven  3000 Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-017-0196-z"},{"key":"e_1_2_6_3_1","first-page":"S72","article-title":"The vitamin D3 analog calcipotriol suppresses the number and antigen\u2010presenting function of Langerhans cells in normal human skin","volume":"1","author":"Dam T N","year":"1996","journal-title":"J Invest Dermatol Symp Proc"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb03373.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1046-199X(99)90003-9"},{"key":"e_1_2_6_6_1","first-page":"1","article-title":"Allergic and irritant contact dermatitis","volume":"19","author":"Nosbaum A","year":"2009","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1999.tb05993.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02071.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1046-199X(96)90086-X"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/000155502753601019","article-title":"Allergic contact dermatitis from calcipotriol","volume":"82","author":"Park Y K","year":"2002","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1994.tb00655.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1991.tb01816.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb02457.x"},{"key":"e_1_2_6_14_1","first-page":"756","article-title":"Tolerance to calcitriol and tacalcitol in three patients with allergic contact dermatitis to calcipotriol","volume":"4","author":"Foti C","year":"2005","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1995.tb02094.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb14835.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12910","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T04:51:55Z","timestamp":1695876715000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,8]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/cod.12910"],"URL":"https:\/\/doi.org\/10.1111\/cod.12910","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,8]]}}}