{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:13:49Z","timestamp":1790140429896,"version":"4.0.1"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T00:00:00Z","timestamp":1512432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2016M592515"],"award-info":[{"award-number":["2016M592515"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Ultraviolet (UV) B<\/jats:styled-content> irradiation is known to suppress contact hypersensitivity (CHS<\/jats:styled-content>) responses in mouse models by suppressing immune responses. However, the cellular mechanisms responsible for UVB<\/jats:styled-content>\u2010induced systemic suppression remain unclear. Regulatory B<\/jats:styled-content> cells have been reported to play an inhibitory role during CHS<\/jats:styled-content>. It is presently unknown whether regulatory B<\/jats:styled-content> cells contribute to the effect of UVB<\/jats:styled-content> phototherapy.<\/jats:p><\/jats:sec>Objective<\/jats:title>To investigate the inductive effect of UVB<\/jats:styled-content> on regulatory B<\/jats:styled-content> cells and the underlying mechanisms by using a CHS<\/jats:styled-content> mouse model.<\/jats:p><\/jats:sec>Methods<\/jats:title>CHS<\/jats:styled-content> was induced with oxazolone, and evaluated by histopathology, flow cytometry, and quantitative real\u2010time polymerase chain reaction.<\/jats:p><\/jats:sec>Result<\/jats:title>We found that UVB<\/jats:styled-content> irradiation induced regulatory B<\/jats:styled-content> cell expansion and ameliorated CHS<\/jats:styled-content>. UVB<\/jats:styled-content>\u2010induced regulatory B<\/jats:styled-content> cells contribute to systemic immunosuppression by inhibiting the proliferation of T<\/jats:styled-content> cells. Moreover, we determined that toll\u2010like receptor (TLR<\/jats:styled-content>) 4, the expression of which was upregulated in B<\/jats:styled-content> cells after UVB<\/jats:styled-content> exposure, played an essential role in the induction of regulatory B<\/jats:styled-content> cells.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our data identified regulatory B<\/jats:styled-content> cells as regulators of UVB<\/jats:styled-content>\u2010induced immunosuppression in CHS,<\/jats:styled-content> and suggest the importance of the UVB<\/jats:styled-content>\u2013TLR<\/jats:styled-content>4 axis in the generation of regulatory B<\/jats:styled-content> cells.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12913","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T11:52:32Z","timestamp":1512474752000},"page":"117-130","source":"Crossref","is-referenced-by-count":15,"title":["Regulatory B<\/scp> cells induced by ultraviolet B<\/scp> through toll\u2010like receptor 4 signalling contribute to the suppression of contact hypersensitivity responses in mice"],"prefix":"10.1111","volume":"78","author":[{"given":"Xiaoming","family":"Liu","sequence":"first","affiliation":[{"name":"Shenzhen Key Laboratory for Translational Medicine of Dermatology Shenzhen Peking University\u00a0\u2013\u00a0the Hong Kong University of Science and Technology Medical Centre Shenzhen 518036 China"},{"name":"Department of Dermatology and Venereology Peking University Shenzhen Hospital Shenzhen 518036 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Peking University Shenzhen Hospital Shenzhen 518036 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbin","family":"Gao","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory for Translational Medicine of Dermatology Shenzhen Peking 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