{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:49:47Z","timestamp":1782125387461,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>An increasing incidence of contact allergy to methylisothiazolinone (MI) has been seen, caused, in particular, by cosmetic products and paints. A study from 2015 showed that 93.0% of paints bought in five European countries contained MI. New regulations have been discussed for paints in the EU, which may have influenced this market.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To re\u2010evaluate the use and concentrations of MI and four other isothiazolinones in water\u2010based wall paints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Water\u2010based white wall paints (n\u2009=\u200960) were purchased in retail stores in five European countries: Denmark, France, Germany, Sweden, and the United Kingdom. The paints were analysed for isothiazolione content by the use of high\u2010performance liquid chromatography coupled to ultraviolet detection, and the results were confirmed with high\u2010performance liquid chromatography\u2013tandem mass spectrometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MI was identified in 55 (91.7%) of the paints, with concentrations ranging from 1.1 to 142.7\u2009ppm. The other isothiazolinones were identified in 20.0% [methylchloroisothiazolinone (MCI)] to 88.3% [benzisothiazolinone (BIT)] of the paints. BIT concentrations varied significantly between countries, whereas MI and MCI concentrations did not. There were no statistically significant differences in MI, MCI and BIT concentrations between the current study and the 2015 study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MI and other isothiazolinones are widely used in paints available in Europe. Their use does not seem to be decreasing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12937","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T08:58:44Z","timestamp":1513673924000},"page":"246-253","source":"Crossref","is-referenced-by-count":52,"title":["Isothiazolinones are still widely used in paints purchased in five European countries: a follow\u2010up study"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6079-3263","authenticated-orcid":false,"given":"Andreas V.","family":"Thomsen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy, National Allergy Research Centre Copenhagen University Hospital Herlev and Gentofte  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob F.","family":"Schwensen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, National Allergy Research Centre Copenhagen University Hospital Herlev and Gentofte  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossana","family":"Bossi","sequence":"additional","affiliation":[{"name":"Department of Environmental Science Aarhus University  4000 Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piu","family":"Banerjee","sequence":"additional","affiliation":[{"name":"St John's Institute of Dermatology Guy's Hospital  London SE1 9RT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Gim\u00e9nez\u2010Arnau","sequence":"additional","affiliation":[{"name":"Laboratoire de Dermatochimie CNRS and University of Strasbourg  67091 Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Pierre","family":"Lepoittevin","sequence":"additional","affiliation":[{"name":"Laboratoire de Dermatochimie CNRS and University of Strasbourg  67091 Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Lid\u00e9n","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine Karolinska Institutet  171 77 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Uter","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Biometry and Epidemiology Friedrich\u2010Alexander University  91054 Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R.","family":"White","sequence":"additional","affiliation":[{"name":"St John's Institute of Dermatology Guy's Hospital  London SE1 9RT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, National Allergy Research Centre Copenhagen University Hospital Herlev and Gentofte  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,19]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"European Chemicals Agency (ECHA). Guidance on the Application of the CLP Criteria Version 5.0 July 2017. Available at:https:\/\/echa.europa.eu\/documents\/10162\/23036412\/clp_en.pdf\/58b5dc6d\u2010ac2a\u20104910\u20109702\u2010e9e1f5051cc5(last accessed 1 October 2017)."},{"key":"e_1_2_5_3_1","unstructured":"European Chemicals Agency (ECHA). C&L inventory. Available at:https:\/\/echa.europa.eu\/information\u2010on\u2010chemicals\/cl\u2010inventory\u2010database(last accessed 1 October 2017)."},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12235"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12416"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12700"},{"key":"e_1_2_5_7_1","first-page":"1301","article-title":"On benzisothiazolinones: a series with a range of bacteriostatic and fungistatic activity","volume":"14","author":"Fischer R","year":"1964","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91318-4"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12098"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12123"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12249"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12149"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12322"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12733"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/es500236m"},{"key":"e_1_2_5_16_1","unstructured":"European Chemicals Agency (ECHA). 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