{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:17Z","timestamp":1787014037859,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T00:00:00Z","timestamp":1512604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Natural ingredients have variable compositions, so their allergenic potencies may differ.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To retrospectively analyse subjects reacting to herbal remedies over the past 27\u2009years, with the aim of (i) evaluating demographic characteristics and lesion locations, (ii) describing the frequencies of positive patch test reactions, (iii) identifing sensitization sources, and (iv) studying concomitant sensitivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>In total, 15980 patients were patch tested between 1990 and 2016 with the European baseline series and\/or other series, product(s) used, and, whenever possible, the respective ingredients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Altogether, 8942 (56%) of 15\u2009980 patients presented with at least one positive reaction. Reactions to topical herbal medicines, most often applied to treat an eczematous condition, leg ulcers, or other wounds, were seen in 125 (0.8%), that is, 1.4% of the contact\u2010allergic subjects. Hands, legs and feet were the most frequently affected body sites. Twenty\u2010one botanical allergens were identified, the commonest being\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Myroxylon pereirae<\/jats:italic>\n                      <\/jats:styled-content>\n                      (balsam of Peru), Compositae plants, and tincture of benzoin. Many patients presented with multiple positive test reactions, and some did not react to the commercial allergens but only to the products used.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Topical herbal remedies should not be applied on damaged skin, as multiple sensitization may develop. Moreover, patch testing with the culprit products is important for the diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.12939","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T00:58:39Z","timestamp":1512608319000},"page":"177-184","source":"Crossref","is-referenced-by-count":47,"title":["Allergic contact dermatitis caused by topical herbal remedies: importance of patch testing with the patients' own products"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0927-3104","authenticated-orcid":false,"given":"Liesbeth","family":"Gilissen","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospitals KU Leuven  3000 Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Huygens","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospitals KU Leuven  3000 Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9805-3439","authenticated-orcid":false,"given":"An","family":"Goossens","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospitals KU Leuven  3000 Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1992.tb03278.x"},{"key":"e_1_2_7_3_1","first-page":"247","article-title":"Botanicals in dermatology. 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