{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:53:24Z","timestamp":1740124404593,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T00:00:00Z","timestamp":1517529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Concern about causing active sensitization when patch testing is performed with <jats:italic>p<\/jats:italic>\u2010phenylenediamine (PPD) 1% pet. has led to a recommendation to use PPD 0.3% pet. as a potentially safer preparation. However, the dose per area of allergen delivered, and hence the risk of active sensitization, depend on the amount dispensed into the patch test chamber, which can vary widely.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate whether patch testing with equivalent doses of different concentrations of PPD in pet. is associated with similar outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventeen known PPD\u2010sensitive subjects were patch tested with different volumes and concentrations of PPD in pet. that deliver the same allergen dose per unit area (6\u2009mg of PPD 1% pet. and 20\u2009mg of PPD 0.3% pet. in Finn Chambers\u00ae, both equivalent to \u223c\u20090.09\u2009mg\/cm<jats:sup>2<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven patients (65%) had positive reactions to both doses; 4 patients (24%) had negative results [percentage agreement of 88% (15\/17)]. One patient each had a positive reaction to only one dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The 88% concordance suggests that dose per unit area is more important in determining reactions to allergens than the excipient volume dispensed. Patch testing with a smaller volume of 1% PPD may be a reasonable alternative to testing with 20\u2009mg of 0.3% PPD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12951","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T09:44:52Z","timestamp":1517564692000},"page":"335-340","source":"Crossref","is-referenced-by-count":3,"title":["Different concentrations and volumes of <i>p<\/i>\u2010phenylenediamine in pet. (equivalent doses) are associated with similar patch test outcomes: a pilot study"],"prefix":"10.1111","volume":"78","author":[{"given":"Flemming","family":"Andersen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Centre, Odense University Hospital, Odense 5000, Denmark, and Dermatological Investigations Scandinavia, Department of Clinical Research University of Southern Denmark  Odense 5230 Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2011-7380","authenticated-orcid":false,"given":"Carsten R.","family":"Hamann","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Herlev and Gentofte Hospital University of Copenhagen  Hellerup 2900 Denmark"},{"name":"School of Health and Medical Science, Graduate Programme in Public Health and Epidemiology University of Copenhagen  Copenhagen 1165 Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus E.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre, Odense University Hospital, Odense 5000, Denmark, and Dermatological Investigations Scandinavia, Department of Clinical Research University of Southern Denmark  Odense 5230 Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2052-3725","authenticated-orcid":false,"given":"Dathan","family":"Hamann","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine The Ohio State University  Columbus OH 43230 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Sager","sequence":"additional","affiliation":[{"name":"Loma Linda University School of Medicine  Loma Linda CA 92350 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curtis","family":"Hamann","sequence":"additional","affiliation":[{"name":"Contact Dermatitis Institute  Phoenix AZ 85008 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,2]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"PollitzerP M KamerosA J. Hazardous substances and articles; administration and enforcement regulations: notice of proposed rulemaking; revisions to supplemental definition of \u2018strong\u2019 sensitizer. Consumer Product Safety Commission 16 CFR Part 1500 2013. Available at:https:\/\/www.cpsc.gov\/s3fs\u2010public\/pdfs\/foia_strongsensitizer.pdf(last accessed 16 August 2017)."},{"key":"e_1_2_5_3_1","first-page":"53","article-title":"P\u2010Phenylenediamine","volume":"17","author":"DeLeo V A","year":"2006","journal-title":"Dermatitis"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01427.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07159.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12075"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e31829f28ac"},{"volume-title":"Patch Testing and Prick Testing","year":"2009","author":"Lachapelle J","key":"e_1_2_5_8_1"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01547.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000225"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01198.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08644.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12164"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.470207.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05837.x"},{"key":"e_1_2_5_16_1","first-page":"365","volume-title":"Contact Dermatitis","author":"Wahlberg J E","year":"2011"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2005.10.008"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.00985.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01094.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1984.tb00957.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01098.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2015.05.001"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2006.00803.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2006.00863.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000297"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01093.x"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12951","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12951","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:15:36Z","timestamp":1695536136000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,2]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/cod.12951"],"URL":"https:\/\/doi.org\/10.1111\/cod.12951","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"type":"print","value":"0105-1873"},{"type":"electronic","value":"1600-0536"}],"subject":[],"published":{"date-parts":[[2018,2,2]]}}}