{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:22:21Z","timestamp":1772223741554,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T00:00:00Z","timestamp":1516579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The diagnostic approach to drug hypersensitivity includes a detailed medical history, clinical examination, and skin testing and\/or oral challenge with a culprit or alternative drug, depending on the type of reaction and the suspected drugs. Although skin testing is considered to be rather safe, cutaneous and systemic, including fatal, reactions have been described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To report 3 cases with generalized delayed reactions after skin testing with clindamycin, and to review the existing literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thorough clinical examination, blood tests and prick, intradermal and patch tests were performed in 3 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients experienced generalized maculopapular exanthema after intradermal and patch testing with clindamycin and amoxicillin in the first patient, and clindamycin alone in the second and third patient. None of the patients showed immediate reactions to skin tests, while positive intradermal reactions after 24\u2009h to amoxicillin and clindamycin were observed in the first patient, and positive intradermal reactions after 24\u2009h to clindamycin were observed in the second and third patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Skin testing with clindamycin in the diagnosis of drug hypersensitivity carries some risk of adverse reactions. A stepwise and individual diagnostic work\u2010up, considering potential risk factors, and testing in a specialized centre with emergency equipment available is highly recommended.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12956","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T15:47:13Z","timestamp":1516636033000},"page":"274-280","source":"Crossref","is-referenced-by-count":15,"title":["Generalized reactions during skin testing with clindamycin in drug hypersensitivity: a report of 3 cases and review of the literature"],"prefix":"10.1111","volume":"78","author":[{"given":"Eleni","family":"Papakonstantinou","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Comprehensive Allergy Centre, Hannover Medical School 30625, Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical Centre\u00a0\u2013\u00a0University of Freiburg, Faculty of Medicine, University of Freiburg 79104 Freiburg im Breisgau Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan H.","family":"R\u00f6hrbein","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Comprehensive Allergy Centre, Hannover Medical School 30625, Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothea","family":"Wieczorek","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Comprehensive Allergy Centre, Hannover Medical School 30625, Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Kapp","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Comprehensive Allergy Centre, Hannover Medical School 30625, Hannover 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