{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T19:16:15Z","timestamp":1775330175895,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T00:00:00Z","timestamp":1517788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Occupational allergic contact dermatitis (ACD) in healthcare workers (HCWs) is common, but systemic antibiotics are rarely reported as the cause.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Characterize occupational ACD by handling systemic antibiotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective analysis was performed of ACD caused by systemic antibiotics among HCWs patch tested between 2010 and 2016 with a series of systemic antibiotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We studied 4 female nurses aged 28\u201347\u2009years who developed ACD while working in surgical departments. They had eczema of the hands, and forearms or face, and 1 patient, who previously had exanthema caused by flucloxacillin, also developed a generalized rash following airborne exposure to systemic antibiotics. Patch tests showed positive reactions to ampicillin and cefazolin in 1 patient, to cefotaxime and ceftriaxone in 2 patients, and to several penicillins in another patient. Three patients also reacted to rubber allergens, fragrances, and\/or preservatives. All patients admitted having direct and sporadic exposure to systemic antibiotic solutions. Avoidance resulted in a significant improvement of ACD, but 1 patient had to change job.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Occupational ACD caused by \u03b2\u2010lactam antibiotics, particularly cephalosporins, is significant in HCWs. Cross\u2010reactions between \u03b2\u2010lactams are similar to those described in non\u2010immediate drug eruptions. A relationship between systemic delayed drug hypersensitivity and ACD, as observed in one case, suggests that patients should avoid future use of the antibiotic to which they are sensitized.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12960","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T06:43:10Z","timestamp":1517812990000},"page":"281-286","source":"Crossref","is-referenced-by-count":27,"title":["Occupational allergic contact dermatitis caused by antibiotics in healthcare workers\u00a0\u2013\u00a0relationship with non\u2010immediate drug eruptions"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3357-9157","authenticated-orcid":false,"given":"V\u00edtor","family":"Pinheiro","sequence":"first","affiliation":[{"name":"Occupational Health Department Coimbra Hospital and University Centre (CHUC)  Praceta Prof. Mota Pinto, 3000\u2010075 Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catarina","family":"Pestana","sequence":"additional","affiliation":[{"name":"Occupational Health Department Coimbra Hospital and University Centre (CHUC)  Praceta Prof. Mota Pinto, 3000\u2010075 Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Pinho","sequence":"additional","affiliation":[{"name":"Dermatology Department Coimbra Hospital and University Centre (CHUC)  Praceta Prof. Mota Pinto, 3000\u2010075 Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Antunes","sequence":"additional","affiliation":[{"name":"Occupational Health Department Coimbra Hospital and University Centre (CHUC)  Praceta Prof. Mota Pinto, 3000\u2010075 Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6842-1360","authenticated-orcid":false,"given":"Margarida","family":"Gon\u00e7alo","sequence":"additional","affiliation":[{"name":"Dermatology Department Coimbra Hospital and University Centre (CHUC)  Praceta Prof. Mota Pinto, 3000\u2010075 Coimbra Portugal"},{"name":"Dermatology Clinic, Medicine Faculty Coimbra University  Praceta Prof. Mota Pinto, 3000\u2010075 Coimbra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14319"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14316"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.20344\/amp.6605"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12333"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12099"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12616"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.02027.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e318290c57f"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2011-100315"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01718.x"},{"key":"e_1_2_6_12_1","first-page":"475","volume-title":"Contact Dermatitis","author":"Gon\u00e7alo M","year":"2010"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.450504.x"},{"key":"e_1_2_6_14_1","first-page":"49","article-title":"Occupational allergic contact dermatitis in healthcare workers","volume":"75","author":"Pinheiro V","year":"2017","journal-title":"Rev da Soc Port Dermatologia"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2012.01.004"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000248"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13796"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.450601.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12330"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000124"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1994.tb01945.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb00423.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1996.tb02186.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.5070\/D389C0S3ST","article-title":"Occupational contact allergy to cephalosporins","volume":"17","author":"Antunes J","year":"2011","journal-title":"Dermatol Online J"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/15459624.2014.908259"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2011.12.037"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12022"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12313"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07704.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12720"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12125"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-016-0594-9"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-017-0691-4"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.01.025"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12299"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12960","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12960","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:00:12Z","timestamp":1695492012000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,5]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/cod.12960"],"URL":"https:\/\/doi.org\/10.1111\/cod.12960","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,5]]}}}