{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T21:02:39Z","timestamp":1773262959905,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T00:00:00Z","timestamp":1518998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>An inverse relationship between disease severity and health\u2010related quality of life (HR\u2010QoL) in patients with hand eczema is well established, but modifying effects of demographic variables have been less well studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify the influence of metropolitan versus non\u2010metropolitan residence on the relationship between disease severity and HR\u2010QoL in patients with occupational hand eczema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The city of Copenhagen and the rest of Zealand were defined as metropolitan and non\u2010metropolitan areas, respectively. Participants were 773 persons with occupational hand eczema. A questionnaire on the severity of hand eczema and HR\u2010QoL was sent to all participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The odds for reporting moderate to high severity of occupational hand eczema were significantly lower in the metropolitan population than in the non\u2010metropolitan population [odds ratio (OR): 0.42; 95%CI: 0.23\u20130.75], whereas low dermatology\u2010related quality of life was more prevalent in metropolitan than in non\u2010metropolitan patients (OR: 1.31; 95%CI: 0.83\u20132.05), indicating that hand eczema had a more pronounced negative effect in metropolitan patients, in spite of less severe eczema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data indicate that area of residence has a modifying effect on the relationship between disease severity and HR\u2010QoL, with a more negative impact on HR\u2010QoL in metropolitan than in non\u2010metropolitan areas. This information is important with respect to fully appreciating the burden of occupational hand eczema.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12962","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T16:48:05Z","timestamp":1519231685000},"page":"348-354","source":"Crossref","is-referenced-by-count":19,"title":["Impact of hand eczema on quality of life: metropolitan versus non\u2010metropolitan areas"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3702-1409","authenticated-orcid":false,"given":"Line B.","family":"N\u00f8rreslet","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Copenhagen, Bispebjerg Hospital  2400 Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tove","family":"Agner","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Copenhagen, Bispebjerg Hospital  2400 Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Copenhagen, Bispebjerg Hospital  2400 Copenhagen Denmark"},{"name":"Department of Occupational and Environmental Medicine University of Copenhagen, Bispebjerg Hospital  2400 Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels E.","family":"Ebbeh\u00f8j","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine University of Copenhagen, Bispebjerg Hospital  2400 Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens P.","family":"Bonde","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine University of Copenhagen, Bispebjerg Hospital  2400 Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8800-9613","authenticated-orcid":false,"given":"Maja H.","family":"Fisker","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Copenhagen, Bispebjerg Hospital  2400 Copenhagen Denmark"},{"name":"Department of Occupational and Environmental Medicine University of Copenhagen, Bispebjerg Hospital  2400 Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01718.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810364557"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01669.x"},{"key":"e_1_2_7_5_1","unstructured":"Arbejdsmarkedets Erhvervssikring. 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