{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T20:51:03Z","timestamp":1771361463014,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Preventive skin care programmes have shown beneficial effects on the prevalence and severity of hand eczema, but most trials only report short\u2010term outcomes. One such trial was the randomized Hand Eczema Trial (HET, 2009) investigating the effects of a secondary prevention programme in healthcare workers. Positive results have been reported at 5\u2010month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the long\u2010term (42\u201347\u2009months) effects of the HET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present study was a follow\u2010up questionnaire study on the effect of the intervention. Outcomes were the presence and severity of hand eczema, health\u2010related quality of life (HR\u2010QoL), skin protective behaviour, and knowledge of skin protection. A supplementary outcome was general improvement\/worsening of hand eczema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparison of the outcomes at follow\u2010up showed no marked differences between the two groups. General improvement was reported by 70% in the intervention group and by 54% in the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.25). A small, statistically significant improvement was found regarding HR\u2010QoL in the intervention group only (<jats:italic>p<\/jats:italic>\u2009=\u20090.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The impact of an intervention that is effective after 5\u2009months is attenuated over time, with no long\u2010term effect on the outcomes examined. We suggest that skin care education should be repeated at regular intervals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12964","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T08:03:19Z","timestamp":1519632199000},"page":"329-334","source":"Crossref","is-referenced-by-count":20,"title":["A long\u2010term follow\u2010up study of the Hand Eczema Trial (HET): a randomized clinical trial of a secondary preventive programme introduced to Danish healthcare workers"],"prefix":"10.1111","volume":"78","author":[{"given":"Christine","family":"Graversgaard","sequence":"first","affiliation":[{"name":"Department of Dermatology Zealand University Hospital  4000 Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tove","family":"Agner","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bispebjerg Hospital  2400 Copenhagen Denmark"},{"name":"Department of Biomedical Sciences University of Copenhagen  2200 Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor B. 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