{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T15:40:02Z","timestamp":1782315602184,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T00:00:00Z","timestamp":1519171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The essential physical role, visibility and social importance of the hands place a major psychological burden on patients with hand eczema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to identify the psychological, social and clinical characteristics of patients with hand eczema, in particular the prevalences of depression, anxiety, suicidal ideation, and comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Data on patients with hand eczema were analysed from a large European multicentre study conducted with dermatology outpatients from 13 countries. Groups of patients and controls were compared to analyse the psychological burden of hand eczema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Female patients with hand eczema had higher Hospital Anxiety and Depression Scale (HADS) scores for anxiety (<jats:italic>n<\/jats:italic>\u2009=\u200986, median\u2009=\u20097.0) than controls (<jats:italic>n<\/jats:italic>\u2009=\u2009900, median\u2009=\u20095.0, <jats:italic>P<\/jats:italic>\u2009=\u2009.02), and for depression (median\u2009=\u20094.0) than controls (3.0, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Patients with high suicidal ideation, with low socioeconomic status and who were widowed or divorced were more likely to fulfil the HADS criteria for anxiety [odds ratio (OR)\u2009&gt;\u20091, <jats:italic>P<\/jats:italic>\u2009=\u2009.038, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001, and <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001, respectively]. The median Dermatology Life Quality Index score was 7.0 (<jats:italic>n<\/jats:italic>\u2009=\u200968).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This study identifies a specific psychological burden experienced by hand eczema patients, highlighting the need for focused psychosocial interventions. Physicians in particular should be aware of the need to identify anxiety and depression in female patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12973","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T20:30:05Z","timestamp":1519245005000},"page":"406-412","source":"Crossref","is-referenced-by-count":51,"title":["The psychosocial burden of hand eczema: Data from a European dermatological multicentre study"],"prefix":"10.1111","volume":"78","author":[{"given":"Servando E.","family":"Marron","sequence":"first","affiliation":[{"name":"Department of Dermatology Royo Villanova Hospital, Aragon Health Sciences Institute (IACS)  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1917-6906","authenticated-orcid":false,"given":"Lucia","family":"Tomas\u2010Aragones","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Zaragoza, Aragon Health Sciences Institute (IACS)  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Navarro\u2010Lopez","sequence":"additional","affiliation":[{"name":"Bioinformation Group, Aragon Health Sciences Institute (IACS)  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Gieler","sequence":"additional","affiliation":[{"name":"Department of Dermatology Justus Liebig University  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Kupfer","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology Justus Liebig University  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence J.","family":"Dalgard","sequence":"additional","affiliation":[{"name":"Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders Innlandet Hospital Trust  Brumunddal Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Lien","sequence":"additional","affiliation":[{"name":"Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders Innlandet Hospital Trust  Brumunddal Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew Y.","family":"Finlay","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Wound Healing Cardiff University School of Medicine  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Poot","sequence":"additional","affiliation":[{"name":"Department of Dermatology ULB Hospital ERASME  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Linder","sequence":"additional","affiliation":[{"name":"Section of Biostatistics University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek C.","family":"Szepietowski","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wroclaw Medical University  Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Misery","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Brest  Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor B. E.","family":"Jemec","sequence":"additional","affiliation":[{"name":"Department of Dermatology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry","family":"Romanov","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychosomatics I. M. Sechenov First Moscow State Medical University  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Sampogna","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit Istituto Dermopatico dell\u2019Immacolata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csanad","family":"Szabo","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilknur K.","family":"Altunay","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sisli Etfal Teaching and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Spillekom\u2010van Koulil","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Balieva","sequence":"additional","affiliation":[{"name":"Department of Dermatology Stavanger University Hospital  Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faraz M.","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Wound Healing Cardiff University School of Medicine  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon A.","family":"Halvorsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Oslo University Hospital and Institute of Clinical Medicine, University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro C.","family":"Marijuan","sequence":"additional","affiliation":[{"name":"Bioinformation Group, Aragon Health Sciences Institute (IACS)  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.446"},{"key":"e_1_2_5_3_1","first-page":"107","article-title":"Skin disease in Lambeth. 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