{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T23:44:34Z","timestamp":1775691874872,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T00:00:00Z","timestamp":1529884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Basilea Pharmaceutica International"},{"name":"Glaxo SmithKline AG Switzerland"},{"name":"Basilea Pharmaceutica International AG"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hand eczema (HE) is common and may follow a chronic disease course. So far, prospective studies investigating the risk factors for disease progression as a prerequisite for targeted prevention are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the overall association of HE\u2010associated factors with clinical and quality of life (QoL) improvement during a follow\u2010up of 2\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of the prospective patient cohort (<jats:italic>N<\/jats:italic>\u2009=\u2009199) followed by the Swiss chronic HE (CHE) registry on long\u2010term patient management (CARPE\u2010CH) were analysed by means of both classic regression and semantic map analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both severity of HE and QoL significantly improved over the period of 2 years (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). However, 20% of patients had moderate to severe HE after 2 years of follow\u2010up. As factors associated with an unfavourable CHE clinical course and QoL, environmental exposures, male sex, occupational skin disease, job loss or change at baseline, allergic contact dermatitis, a chronic disease course, palmar localization and widespread eczema were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Analysis of prospective data from CARPE\u2010CH shows a complex pattern of associations among variables as shown by semantic map and classic statistical analyses. Factors related to occupational exposure had the highest impact on CHE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13041","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T04:36:42Z","timestamp":1529987802000},"page":"136-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Chronic hand eczema: A prospective analysis of the Swiss CARPE registry focusing on factors associated with clinical and quality of life improvement"],"prefix":"10.1111","volume":"79","author":[{"given":"Simone","family":"Cazzaniga","sequence":"first","affiliation":[{"name":"Department of Dermatology, Inselspital Bern University Hospital  Bern Switzerland"},{"name":"Centro Studio, Italian Group for Epidemiological Research in Dermatology (GISED)  Bergamo Italy"},{"name":"Graduate School for Cellular and Biomedical Sciences University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara K.","family":"Ballmer\u2010Weber","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich  Zurich Switzerland"},{"name":"Faculty of Medicine University of Zurich  Zurich Switzerland"},{"name":"Allergy Unit, Clinic of Dermatology and Allergology Cantonal Hospital St Gallen  St. Gallen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"Gr\u00e4ni","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Spring","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Lausanne CHUV  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6683-3975","authenticated-orcid":false,"given":"Andreas","family":"Bircher","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Anliker","sequence":"additional","affiliation":[{"name":"Clinic of Dermatology and Allergology Cantonal Hospital St Gallen  St Gallen Switzerland"},{"name":"Haut\u00e4rzte am Graben  Winterthur Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Katharina","family":"Sonntag","sequence":"additional","affiliation":[{"name":"Department of Dermatology Cantonal Hospital Aarau  Aarau Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Piletta","sequence":"additional","affiliation":[{"name":"Department of Dermatology Geneva University Hospitals (HUG)  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Dermatology Geneva University Hospitals (HUG)  Geneva Switzerland"},{"name":"Dermatology Office  Versoix Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas L.","family":"Diepgen","sequence":"additional","affiliation":[{"name":"Department of Clinical Social Medicine, Occupational and Environmental Dermatology University Hospital, Ruprecht Karls University  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3805-8219","authenticated-orcid":false,"given":"Christian","family":"Apfelbacher","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Preventive Medicine University of Regensburg  Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Naldi","sequence":"additional","affiliation":[{"name":"Centro Studio, Italian Group for Epidemiological Research in Dermatology (GISED)  Bergamo Italy"},{"name":"Department of Dermatology San Bortolo Hospital  Vicenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Borradori","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Inselspital Bern University Hospital  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8965-9407","authenticated-orcid":false,"given":"Dagmar","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Inselspital Bern University Hospital  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01669.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1565"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09139.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1093"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-13-14"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06494.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09987.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12869"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.02024.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13479"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2011.07694_suppl.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15660"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06270.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23621.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365390"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2007.01.008"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9781139164849"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13371"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12800"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12045"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12963"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02105.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01729.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01611.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12674"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550510036658"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12206"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01935.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14019"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1111"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12130"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08487.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2016.1227422"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.13041","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.13041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T23:01:31Z","timestamp":1694991691000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.13041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,25]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/cod.13041"],"URL":"https:\/\/doi.org\/10.1111\/cod.13041","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,25]]},"assertion":[{"value":"2018-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}