{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T03:11:01Z","timestamp":1775617861650,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T00:00:00Z","timestamp":1529452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Kirsten and Volmer Rask Nielsen's Fund"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The sunflower family of plants (Compositae\u2009=\u2009Asteraceae) is currently the most allergenic plant family worldwide, according to the number of sensitizing species. Secondary plant metabolites, including the allergenic sesquiterpene lactones present in Compositae plants, may occur in food items either through their presence in, or through contamination of, plant\u2010based raw materials, or through their occurrence in products of non\u2010plant origin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyse biodynamic, organic and conventional milk for the presence of the sesquiterpene lactone parthenolide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The content of parthenolide in the milk samples was investigated in dichloromethane extracts obtained by liquid\u2010liquid extraction, followed by gas chromatography\u2010mass spectrometry analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The concentration of parthenolide was 0.07\u2009\u00b10.004\u2009ppm in biodynamic milk, 0.05\u2009\u00b10.002\u2009ppm in organic milk, and not detectable (&lt;0.002\u2009ppm) in conventional milk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first report of a potent contact allergen in milk. There seems to be an association between the time that the dairy cattle spend grazing and the amount of parthenolide detected. Although the concentration is low, it is estimated to be high enough to elicit dermatitis in the most sensitive persons by direct contact with the milk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13043","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T07:32:19Z","timestamp":1529479939000},"page":"208-212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Parthenolide in Danish biodynamic and organic milk: A new source of exposure to an allergenic sesquiterpene lactone"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9738-6613","authenticated-orcid":false,"given":"Evy","family":"Paulsen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital, University of Southern Denmark  Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rime B.","family":"El\u2010Houri","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Biotechnology and Environmental Technology University of Southern Denmark  Odense M Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus E.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital, University of Southern Denmark  Odense C Denmark"},{"name":"Department of Clinical Research, Odense University Hospital University of Southern Denmark  Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5035-9201","authenticated-orcid":false,"given":"Lars P.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Biotechnology and Environmental Technology University of Southern Denmark  Odense M Denmark"},{"name":"Department of Chemistry and Bioscience Aalborg University  Aalborg \u00d8 Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfami.7.6.523"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.470401.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0176-1617(87)80208-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"26877","DOI":"10.1016\/S0021-9258(19)61456-0","article-title":"Metabolite profiling of sesquiterpene lactones from Lactuca species: major latex components are novel oxalate and sulfate conjugates of lactucin and its derivatives","volume":"275","author":"Sessa RA","year":"2000","journal-title":"J Biol Chem"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2006.00709.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12671"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408444.2013.813905"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf60201a012"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1573(199711)11:7<479::AID-PTR129>3.0.CO;2-W"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jexbot\/50.333.435"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3382"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-961110"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1991.tb01684.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ffj.2730050310"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50078a005"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07674.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2527\/1990.683892x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/19440049.2017.1382726"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-011-9346-0"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2017.11.010"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb400626w"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR14710.1"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:DRUG.0000026256.38560.be"},{"key":"e_1_2_7_25_1","unstructured":"KarydiE KudahlA B VaarstM.SOLID participatory research from Denmark: Use of herbs in pastures for dairy cows: Farmers\u2019 experience pasture coverage analyses and literature survey of Danish research results2015.http:\/\/orgprints.org\/28754. 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