{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:34:23Z","timestamp":1790879663291,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,8,6]],"date-time":"2018-08-06T00:00:00Z","timestamp":1533513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Board of Health's pool for projects promoting health and prevention of disease"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Preservatives such as formaldehyde and formaldehyde\u2010releasers are common causes of contact allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine trends in contact allergy to formaldehyde and formaldehyde\u2010releasers in patch tested patients in Denmark over a 10\u2010year period (2007\u20102016), and to investigate relevant sources of formaldehyde among the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional registry study on patch test data from patients tested with formaldehyde and formaldehyde\u2010releasers (<jats:italic>N<\/jats:italic> = 8463) was performed. The presence of released formaldehyde in products from formaldehyde\u2010allergic patients was identified with chemical analyses (chromotropic acid or acetylacetone test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of contact allergy to formaldehyde 1% was 1.5%, and ranged between 0.97% and 2.3%, with a decreasing trend in this 10\u2010year period. Contact allergy to formaldehyde 2% was found in 2.4%, and no significant trend was observed. Quaternium\u201015 was the formaldehyde\u2010releaser most often positive (0.86%). Patients allergic to formaldehyde often had simultaneous positive patch test reactions to formaldehyde\u2010releasers (36%). Almost 63% of the patients with formaldehyde allergy used products that released formaldehyde; cosmetics were the most common sources.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although contact allergy to formaldehyde 1% decreased in this 10\u2010year time period, contact allergies to formaldehyde and formaldehyde\u2010releasers overall remain frequent in patients. In most cases, formaldehyde\u2010allergic patients are exposed to \u22651 products containing formaldehyde. Improved regulation on permitted amounts of free formaldehyde in cosmetics is still warranted, including direct labelling of formaldehyde when it is present in small but relevant amounts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13052","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T08:15:09Z","timestamp":1533629709000},"page":"263-269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Ten\u2010year trends in contact allergy to formaldehyde and formaldehyde\u2010releasers"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6638-687X","authenticated-orcid":false,"given":"Ida M.","family":"Fasth","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010Allergology, The National Allergy Research Centre Copenhagen University Hospital Herlev\u2010Gentofte  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4253-6933","authenticated-orcid":false,"given":"Nina H.","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology, The National Allergy Research Centre Copenhagen University Hospital Herlev\u2010Gentofte  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology, The National Allergy Research Centre Copenhagen University Hospital Herlev\u2010Gentofte  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01582.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.01058.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01206501-199103000-00004"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01668.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01631.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14241"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05630.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0925"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02169.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10151.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-03827-3_32"},{"key":"e_1_2_5_13_1","unstructured":"Off J Eur Union.Regulation (EC) No. 1223\/2009 of the European Parliament and of the Council of November 30 2009 on cosmetic products.Off J Eur Union2009:1223.https:\/\/ec.europa.eu\/health\/sites\/health\/files\/endocrine_disruptors\/docs\/cosmetic_1223_2009_regulation_en.pdf(Accessed March 1 2018)."},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb02435.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-03827-3_27"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1996.tb02109.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12726"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000158"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01745.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1988.tb02802.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12148"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12493"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.13052","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.13052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T18:13:44Z","timestamp":1694888024000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.13052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,6]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/cod.13052"],"URL":"https:\/\/doi.org\/10.1111\/cod.13052","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,6]]},"assertion":[{"value":"2018-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}