{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:56:46Z","timestamp":1790110606721,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T00:00:00Z","timestamp":1533600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Allergic contact dermatitis caused by <jats:italic>p<\/jats:italic>\u2010phenylenediamine (PPD) is a health concern for hair dye users. Because of its lower sensitization potency, the PPD derivative 2\u2010methoxymethyl\u2010<jats:italic>p<\/jats:italic>\u2010phenylenediamine (ME\u2010PPD) has been developed as an alternative hair dye for primary prevention. However, cross\u2010elicitation responses can occur in PPD\u2010allergic subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare cross\u2010elicitation responses to ME\u2010PPD in open use and diagnostic patch testing of PPD\u2010allergic subjects with hair dye\u2010related allergic contact dermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Reactions to ME\u2010PPD were investigated in 25 PPD\u2010allergic subjects by performing (1) 45\u2010minute open use testing with a hair dye containing 2.0% of either ME\u2010PPD or PPD, and (2) patch testing with increasing ME\u2010PPD concentrations (0.1%\u20132.0% pet.).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 25 PPD\u2010allergic subjects, 21 (84%) reacted to open use testing with a hair dye containing 2.0% PPD, and testing with 2.0% ME\u2010PPD led to cross\u2010elicitation in 12 (48%). When patch tested with increasing ME\u2010PPD concentrations, 13 (52%) cross\u2010reacted at 0.1% (lowest dose) and 21 (84%) at 2.0% (highest dose), indicating decreased reactivity as compared with published PPD dose\u2010response data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In line with the decreased cross\u2010reactivity of ME\u2010PPD in hair dye open use testing, PPD\u2010allergic subjects show an attenuated cross\u2010elicitation dose response to ME\u2010PPD in patch testing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13078","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T12:47:30Z","timestamp":1533646050000},"page":"288-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Cross\u2010elicitation responses to 2\u2010methoxymethyl\u2010<i>p<\/i>\u2010phenylenediamine in <i>p<\/i>\u2010phenylenediamine\u2010allergic individuals: Results from open use testing and diagnostic patch testing"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0766-4382","authenticated-orcid":false,"given":"Marie L.","family":"Schuttelaar","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2233-7424","authenticated-orcid":false,"given":"Daan","family":"Dittmar","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes G. M.","family":"Burgerhof","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3625-0701","authenticated-orcid":false,"given":"Brunhilde","family":"Bl\u00f6meke","sequence":"additional","affiliation":[{"name":"Department of Environmental Toxicology Trier University  Trier Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Goebel","sequence":"additional","affiliation":[{"name":"Department of Toxicology Coty  Darmstadt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,7]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"SCCS (Scientific Committee on Consumer Safety). Memorandum on hair dye chemical sensitisation. February 26 2013.https:\/\/ec.europa.eu\/health\/scientific_committees\/consumer_safety\/docs\/sccs_s_007.pdf"},{"key":"e_1_2_6_3_1","unstructured":"SCCS (Scientific Committee on Consumer Safety). Opinion on: hydroxyethyl\u2010p\u2010phenylenediamine sulfate COLIPA no. A80.2010.https:\/\/ec.europa.eu\/health\/scientific_committees\/consumer_safety\/docs\/sccs_o_017.pdf"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.11.016"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06742.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2006.00803.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13412"},{"key":"e_1_2_6_9_1","unstructured":"Scientific Committee on Consumer Products. Opinion on: 2\u2010Methyl\u20105\u2010Hydroxyethylaminophenol COLIPA no. A31.2006.https:\/\/ec.europa.eu\/health\/ph_risk\/committees\/04_sccp\/docs\/sccp_o_040.pdf"},{"key":"e_1_2_6_10_1","unstructured":"Scientific Committee on Consumer Products. Opinion on: 2\u2010Methylresorcinol COLIPA no. A44.2008.https:\/\/ec.europa.eu\/health\/ph_risk\/committees\/04_sccp\/docs\/sccp_o_151.pdf"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000230"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10009.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08162.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14390"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12715"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2008.12.008"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.00906.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12783"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics3030021"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.13078","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.13078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T18:13:19Z","timestamp":1694887999000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.13078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,7]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/cod.13078"],"URL":"https:\/\/doi.org\/10.1111\/cod.13078","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,7]]},"assertion":[{"value":"2018-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}